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Integrin beta 1/CD29 Antibody (P5D2) [Phycoerythrin]

Images

 
A549 human lung carcinoma cell line was stained with Mouse Anti-Human Integrin beta 1/CD29 PE-conjugated Monoclonal Antibody (Catalog # FAB17781P, filled histogram) or isotype control antibody (Catalog # IC002P, open ...read more
Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human Integrin beta 1/CD29 PE-conjugated Monoclonal Antibody (Catalog # FAB17781P, filled histogram) or isotype control antibody (Catalog # ...read more
Genetic Strategies: Integrin beta 1/CD29 knockout A549 human lung carcinoma cell line was stained with Mouse Anti-Human Integrin beta 1/CD29 PE-conjugated Monoclonal Antibody (Catalog # FAB17781P, filled ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, KO
Clone
P5D2
Clonality
Monoclonal
Host
Mouse
Conjugate
Phycoerythrin
Validated by:
     

Genetic Strategies

   

Order Details

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Integrin beta 1/CD29 Antibody (P5D2) [Phycoerythrin] Summary

Immunogen
Human skin keratinocytes
Specificity
Detects human Integrin beta 1/CD29 in flow cytometry.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ITGB1
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 10 uL/10^6 cells
  • Knockout Validated
Publications
Read Publications using
FAB17781P in the following applications:

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Integrin beta 1/CD29 Antibody (P5D2) [Phycoerythrin]

  • CD29 antigen
  • CD29
  • Fibronectin receptor subunit beta
  • FNRBVLAB
  • GPIIA
  • Integrin beta 1
  • integrin beta-1
  • integrin VLA-4 beta subunit
  • integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includesMDF2, MSK12)
  • ITGB1
  • MDF2
  • MSK12
  • very late activation protein, beta polypeptide
  • VLA-4 subunit beta
  • VLA-BETA

Background

The Integrin beta 1 subunit, also known as CD29, associates with at least ten different Integrin alpha subunits. It regulates not only its multiple ligands, but activates a signaling cascade in its expressing cells. CD29 is proposed to play a role in cell adhesion, apoptosis, and differentiation (1,2). Over amino acids (aa) 21-728, human and mouse share 92% aa sequence identity.
  1. Barkan, D. and A.F. Chambers (2011) Clin. Cancer Res. 17:7219.
  2. Humphries, M.J. (2000) Biochem. Soc. Trans. 28:311.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Integrin beta 1/CD29 Antibody (FAB17781P)(9)

We have publications tested in 3 confirmed species: Human, Chinese Hamster, Primate - Chlorocebus aethiops (African Green Monkey).

We have publications tested in 2 applications: Flow Cytometry, Neutralization.


Filter By Application
Flow Cytometry
(7)
Neutralization
(1)
All Applications
Filter By Species
Human
(8)
Chinese Hamster
(1)
Primate - Chlorocebus aethiops (African Green Monkey)
(1)
All Species
Showing Publications 1 - 9 of 9.
Publications using FAB17781P Applications Species
Imaizumi, T;Hayashi, R;Kudo, Y;Li, X;Yamaguchi, K;Shibata, S;Okubo, T;Ishii, T;Honma, Y;Nishida, K; Ocular instillation of conditioned medium from mesenchymal stem cells is effective for dry eye syndrome by improving corneal barrier function Scientific reports 2023-08-11 [PMID: 37567940] (Flow Cytometry, Human) Flow Cytometry Human
Cong Li, Yu An, Yu Sun, Fan Yang, Quanchen Xu, Zhiguo Wang Adipose Mesenchymal Stem Cell-Derived Exosomes Promote Wound Healing Through the WNT/ beta -catenin Signaling Pathway in Dermal Fibroblasts Stem Cell Reviews and Reports 2022-08-01 [PMID: 35471485]
C Nusshag, L Boegelein, P Schreiber, S Essbauer, A Osberghaus, M Zeier, E Krautkräme Expression Profile of Human Renal Mesangial Cells Is Altered by Infection with Pathogenic Puumala Orthohantavirus Viruses, 2022-04-15;14(4):. 2022-04-15 [PMID: 35458553] (Flow Cytometry, Chinese Hamster, Human, Primate - Chlorocebus aethiops (African Green Monkey)) Flow Cytometry Chinese Hamster, Human, Primate - Chlorocebus aethiops (African Green Monkey)
SS Sahraei, F Davoodi As, N Kalhor, M Sheykhhasa, H Fazaeli, SS Moud, A Sheikholes A Comparative Study of Gene Expression in Menstrual Blood-Derived Stromal Cells between Endometriosis and Healthy Women BioMed Research International, 2022-01-11;2022(0):7053521. 2022-01-11 [PMID: 35059465] (Flow Cytometry, Human) Flow Cytometry Human
SY Hwang, MU Kuk, JW Kim, YH Lee, YS Lee, HE Choy, SC Park, JT Park ATM mediated-p53 signaling pathway forms a novel axis for senescence control Mitochondrion, 2020-09-17;55(0):54-63. 2020-09-17 [PMID: 32949791] (Flow Cytometry, Human) Flow Cytometry Human
S Mount, P Kanda, S Parent, S Khan, C Michie, L Davila, V Chan, RA Davies, H Haddad, D Courtman, DJ Stewart, DR Davis Physiologic expansion of human heart-derived cells enhances therapeutic repair of injured myocardium Stem Cell Res Ther, 2019-11-04;10(1):316. 2019-11-04 [PMID: 31685023] (Flow Cytometry, Human) Flow Cytometry Human
Park-Min K, Lee E, Moskowitz N, Lim E, Lee S, Lorenzo J, Huang C, Melnick A, Purdue P, Goldring S, Ivashkiv L Negative regulation of osteoclast precursor differentiation by CD11b and beta2 integrin-B-cell lymphoma 6 signaling. J Bone Miner Res, 2013-01-01;28(1):135-49. 2013-01-01 [PMID: 22893614] (Flow Cytometry, Human) Flow Cytometry Human
Burton VJ, Butler LM, McGettrick HM, Stone PC, Jeffery HC, Savage CO, Rainger GE, Nash GB Delay of migrating leukocytes by the basement membrane deposited by endothelial cells in long-term culture. Exp. Cell Res., 2010-11-04;317(3):276-92. 2010-11-04 [PMID: 21056557] (Flow Cytometry, Human) Flow Cytometry Human
Karagiannis ED, Popel AS A systematic methodology for proteome-wide identification of peptides inhibiting the proliferation and migration of endothelial cells. Proc. Natl. Acad. Sci. U.S.A., 2008-09-09;105(37):13775-80. 2008-09-09 [PMID: 18780781] (Neutralization, Human) Neutralization Human

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Product General Protocols

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FAQs for Integrin beta 1/CD29 Antibody (FAB17781P). (Showing 1 - 1 of 1 FAQs).

  1. I'm looking for a good antibody for integrins that works in rats. I would need it for Western Blot, Immunocyto- as well as Immunohistochemistry. I'm especially interested in beta1.
    • I would recommend NB110-57123 as it has been validated using rat samples in WB, IHC-P, and FACS. Although we do not list ICC on the datasheet for this antibody I believe it will work in ICC because it works in Flow Cytometry and has been validated to stain tissue. We have several other Integrin targets. To search for what you are looking for I recommend typing Integrin into the search area at the top of our website, then review the list of suggested targets that poplulate below the search. Once you click on a particular Integrin you can narrow the results with our filter. I recommend filtering to primary antibodies, by target name, species of interest you can filter to rat. If you so choose you can also filter further by application, host, clonality, etc.

Secondary Antibodies

 

Isotype Controls

Additional Integrin beta 1/CD29 Products

Blogs on Integrin beta 1/CD29.

Integrin Beta 1/CD29 - a cell adhesion and cell signaling protein with diverse functions
Integrins are a large family of trasmembrane proteins involved in cell adhesion and form a link between the intracellular cyskeletal proteins and extracellular matrix proteins. Integrins exist as heterodimers consisting of alpha and beta subunits. ...  Read full blog post.

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Bioinformatics

Gene Symbol ITGB1