IL-3R alpha/CD123 Antibody (IL3RA/2947R) [Biotin]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, IHC, MA
Clone
IL3RA/2947R
Clonality
Monoclonal
Host
Rabbit
Conjugate
Biotin

Order Details

IL-3R alpha/CD123 Antibody (IL3RA/2947R) [Biotin] Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
Recombinant fragment of human IL-3R alpha/CD123 protein (around aa 26-171) (exact sequence is proprietary) (Uniprot: P26951)
Localization
Cell Surface, Cytoplasm
Marker
Acute Myeloid Leukemia Marker
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
IL3RA
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Protein Array
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Alternate Names for IL-3R alpha/CD123 Antibody (IL3RA/2947R) [Biotin]

  • CD123 antigen
  • CD123
  • hIL3Ra
  • hIL-3Ra
  • IL-3 R alpha
  • IL-3 receptor subunit alpha
  • IL3R alpha
  • IL-3R alpha
  • IL-3R subunit alpha
  • IL3R
  • IL3RA
  • IL-3Ra
  • IL-3R-alpha
  • IL3RAY
  • IL3RX
  • IL3RY
  • interleukin 3 receptor, alpha (low affinity)
  • interleukin-3 receptor subunit alpha
  • MGC34174

Background

IL3RA (CD123) is a member of the immunoglobulin superfamily that is expressed on hematopoietic progenitors, basophils, mast cells, and megakaryocytes. This transmembrane glycoprotein can bind IL3 with low affinity but cannot transduce signals without association with additional protein partners. CD123 can complex with either common beta chain (CDw131) or the IL3RB chain to form high affinity heterodimeric IL3 receptors. CDw131 can complex with the Alpha subunits of the mouse IL3R, IL5R and GMCSFR to form high affinity receptors, while the IL3RB subunit is specific for IL3 but binds with low affinity. IL3 binding to the receptor complex can induce proliferation and differentiation of hematopoietic cells. It is present in Hematopoietic progenitors, basophils, mast cells and megakaryocytes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol IL3RA