IL-10R alpha Antibody (1B1.3a) [PE]

The IL-10 receptor, IL-10R, is a member of the class II subgroup of the cytokine receptor family and exhibits structural similarity to the interferon receptor. IL-10R is expressed in B cells and T helper cells, as well as in LPS-induced mouse fibroblasts. Overall, mouse IL-10R and human IL-10R share 60% sequence identity at the protein level. Stimulation with IL-10 leads to tyrosine phosphorylation of JAK1 and Tyk2, but not JAK2 or JAK3. In addition to its role as an antagonist of IFN-gamma-mediated macrophage activation, IL-10Ralpha transmits differentiation as well as proliferative signals. IL-10R is constitutively expressed on human natural killer (NK) cells and the direct binding of IL-10 potentiates cytokine production by human NK cells.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

Showing Publication 1 - 1 of 1.

Publication using NB100-63577PE	Applications	Species
Qiu H, Gong S, Xu L et al. MYD88 L265P mutation promoted malignant B cell resistance against T cell-mediated cytotoxicity via upregulating the IL-10/STAT3 cascade Int Immunopharmacol. 2018-09-22 [PMID: 30253331] (Human) Details: Citation using the PE form of this antibody.		Human

Array NB100-63577PE

• IL-10R alpha Antibodies
• IL-10R alpha ELISA Kits
• IL-10R alpha Lysate
• IL-10R alpha Proteins
• IL-10R alpha Proteins and Enzymes