Human TIMP-3 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

Showing Publications 1 - 8 of 8.

Publications using DY973	Applications	Species
K Du, M Wang, N Zhang, P Yu, P Wang, Y Li, X Wang, L Zhang, C Bachert Involvement of the extracellular matrix proteins periostin and tenascin C in nasal polyp remodeling by regulating the expression of MMPs Clinical and translational allergy, 2021-09-06;11(7):e12059. 2021-09-06 [PMID: 34504680] (Human)		Human
S Zhou, L Li, C Chen, Y Chen, L Zhou, FH Zhou, J Dong, L Wang Injectable gelatin microspheres loaded with platelet rich plasma improve wound healing by regulating early inflammation International Journal of Medical Sciences, 2021-03-03;18(9):1910-1920. 2021-03-03 [PMID: 33850460] (Rat)		Rat
RJ Weiss, PN Spahn, AWT Chiang, Q Liu, J Li, KM Hamill, S Rother, TM Clausen, MA Hoeksema, BM Timm, K Godula, CK Glass, Y Tor, PLSM Gordts, NE Lewis, JD Esko Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate Nature Chemical Biology, 2021-04-12;0(0):. 2021-04-12 [PMID: 33846619] (Human)		Human
DF Boyd, EK Allen, AG Randolph, XJ Guo, Y Weng, CJ Sanders, R Bajrachary, NK Lee, CS Guy, P Vogel, W Guan, Y Li, X Liu, T Novak, MM Newhams, TP Fabrizio, N Wohlgemuth, PM Mourani, PALISI Ped, TN Wight, S Schultz-Ch, SA Cormier, K Shaw-Salib, A Pekosz, RE Rothman, KF Chen, Z Yang, RJ Webby, N Zhong, JC Crawford, PG Thomas Exuberant fibroblast activity compromises lung function via ADAMTS4 Nature, 2020-10-28;0(0):. 2020-10-28 [PMID: 33116313] (Mouse)		Mouse
G Ruiz-Gómez, S Vogel, S Möller, MT Pisabarro, U Hempel Glycosaminoglycans influence enzyme activity of MMP2 and MMP2/TIMP3 complex formation - Insights at cellular and molecular level Sci Rep, 2019-03-20;9(1):4905. 2019-03-20 [PMID: 30894640] (Human)		Human
VS Simons, G Lochnit, J Wilhelm, B Ishaque, M Rickert, J Steinmeyer Comparative Analysis of Peptide Composition and Bioactivity of Different Collagen Hydrolysate Batches on Human Osteoarthritic Synoviocytes Sci Rep, 2018-12-07;8(1):17733. 2018-12-07 [PMID: 30531866] (Human)		Human
Fischer , Marlene, Dietmann , Anelia, Beer , Ronny, Broessner , Gregor, Helbok , Raimund, Pfausler , Bettina, Schmutzhard , Erich, Lackner , Peter Differential regulation of matrix-metalloproteinases and their tissue inhibitors in patients with aneurysmal subarachnoid hemorrhage. PLoS ONE, 2013-03-28;8(3):e59952. 2013-03-28 [PMID: 23555845] (Human)		Human
Lamblin N, Ratajczak P, Hot D, Dubois E, Chwastyniak M, Beseme O, Drobecq H, Lemoine Y, Koussa M, Amouyel P, Pinet F Profile of macrophages in human abdominal aortic aneurysms: a transcriptomic, proteomic, and antibody protein array study. J. Proteome Res., 2010-07-02;9(7):3720-9. 2010-07-02 [PMID: 20513153] (Human)		Human

Array DY973

• TIMP-3 Antibodies
• TIMP-3 ELISA Kit
• TIMP-3 Lysate
• TIMP-3 Proteins and Enzyme
• TIMP-3 ELISA