Human RBP4 Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Retinol-binding protein 4 (RBP4) is a Lipocalin superfamily molecule that transports vitamin A (retinol) and retinaldehyde in the serum. Retinaldehyde is the critical chromophore in the rhodopsin photoreceptor, while both it and retinoic acid regulate a multitude of cellular differentiation and proliferation effects through the intracellular receptors RAR and RXR. RBP4 is secreted primarily by hepatocytes and adipocytes into the blood where the RBP4-retinol complex interacts with transthyretin (TTR). Formation of the complex with TTR increases the serum half-life of RBP4 by preventing RBP4 filtration through the kidney. The C-terminally processed forms of RBP4, which do not bind TTR, are normally excreted into the urine but accumulate in the serum during renal failure. RBP4 promotes hyperglycemia, and its upregulation in visceral and liver adipocytes leads to elevated serum levels.

We have publications tested in 2 confirmed species: Human, Mouse.

Showing Publications 1 - 10 of 30. Show All 30 Publications. Collapse Publications.

Publications using DRB400	Applications	Species
Penkert, RR;Jones, BG;Tang, L;Su, Y;Jeha, S;Yang, J;Yang, W;Ferrolino, J;Strength, R;Pui, CH;Cross, SJ;Hurwitz, JL;Wolf, J; Association of Vitamin A and D Deficiencies with Infectious Outcomes in Children Undergoing Intensive Induction Therapy for Acute Lymphoblastic Leukemia The Journal of pediatrics 2024-06-14 [PMID: 38880379] (Human)		Human
Supriya, R;Shishvan, SR;Kefayati, M;Abednatanzi, H;Razi, O;Bagheri, R;Escobar, KA;Pashaei, Z;Saeidi, A;Shahrbanian, S;Bagchi, S;Sengupta, P;Al Kiyumi, MH;Heinrich, KM;Zouhal, H; Astaxanthin Supplementation Augments the Benefits of CrossFit Workouts on Semaphorin 3C and Other Adipokines in Males with Obesity Nutrients 2023-11-16 [PMID: 38004197] (Human)		Human
H L?rincz, B Ratku, S Csiha, I Seres, Z Szabó, G Paragh, M Harangi, S Somodi Impaired Organokine Regulation in Non-Diabetic Obese Subjects: Halfway to the Cardiometabolic Danger Zone International Journal of Molecular Sciences, 2023-02-18;24(4):. 2023-02-18 [PMID: 36835525] (Human)		Human
H Jeong, AT Armstrong, N Isoherrane, L Czuba, A Yang, K Zumpf, J Ciolino, E Torres, CS Stika, KL Wisner Temporal changes in the systemic concentrations of retinoids in pregnant and postpartum women PLoS ONE, 2023-02-16;18(2):e0280424. 2023-02-16 [PMID: 36795769] (Human)		Human
ME Rossholt, K Wendel, M Bratlie, MF Aas, G Gunnarsdot, D Fugelseth, AH Pripp, M Domellöf, K Størdal, T Stiris, SJ Moltu Vitamin A Status in Preterm Infants Is Associated with Inflammation and Dexamethasone Exposure Nutrients, 2023-01-14;15(2):. 2023-01-14 [PMID: 36678312] (Human)		Human
N Patel, RR Penkert, RE Sealy, SL Surman, BG Jones, K Ringwald-S, AC Ross, JL Hurwitz Retinol Binding Protein, Sunlight Hours, and the Influenza Virus-Specific Immune Response Biomedicines, 2022-09-19;10(9):. 2022-09-19 [PMID: 36140423] (Human)		Human
RR Penkert, M Azul, RE Sealy, BG Jones, J Dowdy, RT Hayden, L Tang, AC Ross, JS Hankins, JL Hurwitz Hypothesis: Low Vitamin A and D Levels Worsen Clinical Outcomes When Children with Sickle Cell Disease Encounter Parvovirus B19 Nutrients, 2022-08-19;14(16):. 2022-08-19 [PMID: 36014920] (Human)		Human
N Hirata, M Kiuchi, K Pak, R Fukuda, N Mochimaru, M Mitsui, K Yoshida Association between Maternal Characteristics and Immune Factors TGF-beta1, TGF-beta2, and IgA in Colostrum: An Exploratory Study in Japan Nutrients, 2022-08-09;14(16):. 2022-08-09 [PMID: 36014760] (Human)		Human
MM Hasan, MA Gazi, S Das, SM Fahim, F Hossaini, AR Khan, J Ferdous, MA Alam, M Mahfuz, T Ahmed Gut biomolecules (I-FABP, TFF3 and lipocalin-2) are associated with linear growth and biomarkers of environmental enteric dysfunction (EED) in Bangladeshi children Scientific Reports, 2022-08-16;12(1):13905. 2022-08-16 [PMID: 35974137] (Human)		Human
LC Czuba, EE Fay, J LaFrance, CK Smith, S Shum, SL Moreni, J Mao, N Isoherrane, MF Hebert Plasma Retinoid Concentrations Are Altered in Pregnant Women Nutrients, 2022-03-25;14(7):. 2022-03-25 [PMID: 35405978] (Human)		Human
IL Salazar, AST Lourenço, B Manadas, I Baldeiras, C Ferreira, AC Teixeira, VM Mendes, AM Novo, R Machado, S Batista, MDC Macário, M Grãos, L Sousa, MJ Saraiva, AACC Pais, CB Duarte Posttranslational modifications of proteins are key features in the identification of CSF biomarkers of multiple sclerosis Journal of Neuroinflammation, 2022-02-08;19(1):44. 2022-02-08 [PMID: 35135578] (Human)		Human
J Liu, C Nie, L Xue, Y Yan, S Liu, J Sun, M Fan, H Qian, H Ying, L Wang, Y Li Growth hormone receptor disrupts glucose homeostasis via promoting and stabilizing retinol binding protein 4 Theranostics, 2021-07-13;11(17):8283-8300. 2021-07-13 [PMID: 34373742] (Human)		Human
Tominaga T, Ikemura T, Yada K, Kanda K, Sugama K, Ma S, Choi W, Araya M, Huang J, Nakamura N, Suzuki K The Effects of Beverage Intake after Exhaustive Exercise on Organ Damage, Inflammation and Oxidative Stress in Healthy Males. Antioxidants (Basel), 2021-05-28;10(6):. 2021-05-28 [PMID: 34071378] (Human)		Human
D Tsakogiann, E Kalogera, F Zagouri, E Zografos, D Balalis, G Bletsa Determination of FABP4, RBP4 and the MMP-9/NGAL complex in the serum of women with breast cancer Oncology Letters, 2020-12-04;21(2):85. 2020-12-04 [PMID: 33376518] (Human)		Human
X Wang, Y Huang, J Gao, H Sun, M Jayachandr, S Qu Changes of serum retinol-binding protein 4 associated with improved insulin resistance after laparoscopic sleeve gastrectomy in Chinese obese patients Diabetol Metab Syndr, 2020-01-14;12(0):7. 2020-01-14 [PMID: 31956345] (Human)		Human
H Wessel, A Saeed, J Heegsma, MA Connelly, KN Faber, RPF Dullaart Plasma Levels of Retinol Binding Protein 4 Relate to Large VLDL and Small LDL Particles in Subjects with and without Type 2 Diabetes J Clin Med, 2019-10-25;8(11):. 2019-10-25 [PMID: 31717719] (Human)		Human
D Kostic, GPNS Beozzo, SB do Couto, AHT Kato, L Lima, P Palmeira, VLJ Krebs, V Bunduki, RPV Francisco, M Zugaib, FT Dénes, WB de Carvalh, VHK Koch The role of renal biomarkers to predict the need of surgery in congenital urinary tract obstruction in infants J Pediatr Urol, 2019-03-16;0(0):. 2019-03-16 [PMID: 30979613] (Human)		Human
JY Li, XX Chen, XH Lu, CB Zhang, QP Shi, L Feng Elevated RBP4 plasma levels were associated with diabetic retinopathy in type 2 diabetes Biosci. Rep., 2018-09-12;0(0):. 2018-09-12 [PMID: 30135138] (Human)		Human
YY Zhu, JL Zhang, L Liu, Y Han, X Ge, S Zhao Evaluation of serum retinol-binding protein-4 levels as a biomarker of poor short-term prognosis in ischemic stroke Biosci. Rep., 2018-09-12;0(0):. 2018-09-12 [PMID: 30038059] (Human)		Human
M Du, E Phelps, MJ Balangue, A Dockins, G Moiseyev, Y Shin, S Kane, L Otalora, JX Ma, R Farjo, KM Farjo Transgenic Mice Over-Expressing RBP4 Have RBP4-Dependent and Light-Independent Retinal Degeneration Invest. Ophthalmol. Vis. Sci., 2017-08-01;58(10):4095-4103. 2017-08-01 [PMID: 28813718] (Mouse)		Mouse
G Annibalini, F Lucertini, D Agostini, L Vallorani, A Gioacchini, E Barbieri, M Guescini, L Casadei, A Passalia, M Del Sal, G Piccoli, M Andreani, A Federici, V Stocchi Concurrent Aerobic and Resistance Training Has Anti-Inflammatory Effects and Increases Both Plasma and Leukocyte Levels of IGF-1 in Late Middle-Aged Type 2 Diabetic Patients Oxid Med Cell Longev, 2017-06-21;2017(0):3937842. 2017-06-21 [PMID: 28713486] (Human)		Human
S Karunanith, L Levi, J DeVecchio, G Karagkouni, O Reizes, JD Lathia, MF Kalady, N Noy RBP4-STRA6 Pathway Drives Cancer Stem Cell Maintenance and Mediates High-Fat Diet-Induced Colon Carcinogenesis Stem Cell Reports, 2017-07-06;0(0):. 2017-07-06 [PMID: 28689994] (Human)		Human
JL Hurwitz, BG Jones, RR Penkert, S Gansebom, Y Sun, L Tang, AM Bramley, S Jain, JA McCullers, SR Arnold Low Retinol-Binding Protein and Vitamin D Levels Are Associated with Severe Outcomes in Children Hospitalized with Lower Respiratory Tract Infection and Respiratory Syncytial Virus or Human Metapneumovirus Detection J. Pediatr., 2017-05-31;0(0):. 2017-05-31 [PMID: 28578159] (Human)		Human
M Du, A Martin, F Hays, J Johnson, RA Farjo, KM Farjo Serum retinol-binding protein-induced endothelial inflammation is mediated through the activation of toll-like receptor 4 Mol. Vis., 2017-03-31;23(0):185-197. 2017-03-31 [PMID: 28400700] (Mouse)		Mouse
Talsma E, Verhoef H, Brouwer I, Mburu-de Wagt A, Hulshof P, Melse-Boonstra A Proxy markers of serum retinol concentration, used alone and in combination, to assess population vitamin A status in Kenyan children: a cross-sectional study. BMC Med, 2015-02-11;13(0):30. 2015-02-11 [PMID: 25856672] (Human)		Human
Solini A, Stea F, Santini E, Bruno R, Duranti E, Taddei S, Ghiadoni L Adipocytokine levels mark endothelial function in normotensive individuals. Cardiovasc Diabetol, 2012-08-31;11(0):103. 2012-08-31 [PMID: 22938533] (Human)		Human
Ahn KJ, Choi EA, Kim J, Lee JH, Lee KH, Bang D, Cho SB Increased retinol-binding protein (RBP) 4 and anti-RBP4 antibody in alopecia areata. Br. J. Dermatol., 2011-10-01;165(4):837-44. 2011-10-01 [PMID: 21711327] (Human)		Human
Nakajima H, Nakajima K, Tarutani M, Morishige R, Sano S Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients. Arch. Dermatol. Res., 2011-06-17;303(6):451-5. 2011-06-17 [PMID: 21681565] (Human)		Human
Chan DC, Watts GF, Gan S Nonalcoholic fatty liver disease as the transducer of hepatic oversecretion of very-low-density lipoprotein-apolipoprotein B-100 in obesity. Arterioscler. Thromb. Vasc. Biol., 2010-02-11;30(5):1043-50. 2010-02-11 [PMID: 20150556] (Human)		Human
Solini A, Santini E, Madec S, Rossi C, Muscelli E Retinol-binding protein-4 in women with untreated essential hypertension. Am. J. Hypertens., 2009-06-25;22(9):1001-6. 2009-06-25 [PMID: 19556974] (Human)		Human
Show All 30 Publications. Collapse Publications.

Array DRB400

• RBP4/Retinol-Binding Protein 4 Antibodies
• RBP4/Retinol-Binding Protein 4 Antibody Pair
• RBP4/Retinol-Binding Protein 4 ELISA Kits
• RBP4/Retinol-Binding Protein 4 Lysate
• RBP4/Retinol-Binding Protein 4 Proteins
• RBP4/Retinol-Binding Protein 4 Proteins and Enzymes
• RBP4/Retinol-Binding Protein 4 ELISAs