Human/Mouse Phospho-STAT3 (Y705) DuoSet IC ELISA, 2 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The STAT family of transcription factors, first described as key mediators of interferon signal transduction, are now recognized as signaling factors downstream of many cytokines, growth factors, and hormones. At least seven STATs exist: STAT1, 2, 3, 4, 5a, 5b, and 6. They are responsible for an array of cellular activities including regulating growth, survival, differentiation, motility, and the immune response. They are characterized structurally by the presence of the Src homology 2 (SH2) domain, and a C-terminal tyrosine phosphorylation site. Upon ligand binding, they are recruited to the activated receptor, via their SH2 domains, to receptor-associated tyrosine kinases of the Janus kinase family (JAK). Once phosphorylated by JAK, STATS are free to hetero- or homo-dimerize, and translocate to the nucleus where they bind DNA to regulate gene transcription.

We have publications tested in 2 confirmed species: Human, Mouse.

Showing Publications 1 - 9 of 9.

Publications using DYC4607B-2	Applications	Species
F Chen, S Zhu, R Kang, D Tang, J Liu ATP6V0D1 promotes alkaliptosis by blocking STAT3-mediated lysosomal pH homeostasis Cell Reports, 2022-12-29;42(1):111911. 2022-12-29 [PMID: 36640329] (Human)		Human
T Fukasawa, A Yoshizaki, S Ebata, A Yoshizaki-, Y Asano, A Enomoto, K Miyagawa, Y Kazoe, K Mawatari, T Kitamori, S Sato Single-cell-level protein analysis revealing the roles of autoantigen-reactive B lymphocytes in autoimmune disease and the murine model Elife, 2021-12-02;10(0):. 2021-12-02 [PMID: 34854378] (Human)		Human
F Abdallah, E Henriet, A Suet, A Arar, R Clemençon, JM Malinge, G Lecellier, P Baril, C Pichon miR-21-3p/IL-22 Axes Are Major Drivers of Psoriasis Pathogenesis by Modulating Keratinocytes Proliferation-Survival Balance and Inflammatory Response Cells, 2021-09-26;10(10):. 2021-09-26 [PMID: 34685526] (Human)		Human
Y Jung, M Son, YR Nam, J Choi, JR Heath, S Yang Microfluidic Single-Cell Proteomics Assay Chip: Lung Cancer Cell Line Case Study Micromachines, 2021-09-23;12(10):. 2021-09-23 [PMID: 34683198] (Human)		Human
T Yanagawa, H Sumiyoshi, K Higashi, S Nakao, R Higashiyam, H Fukumitsu, K Minakawa, Y Chiba, Y Suzuki, K Sumida, K Saito, A Kamiya, Y Inagaki Identification of a Novel Bone Marrow Cell-Derived Accelerator of Fibrotic Liver Regeneration Through Mobilization of Hepatic Progenitor Cells in Mice Stem Cells, 2018-10-31;37(1):89-101. 2018-10-31 [PMID: 30270488] (Mouse)		Mouse
FM Ding, RM Liao, YQ Chen, GG Xie, PY Zhang, P Shao, M Zhang Upregulation of SOCS3 in lung CD4+ T cells in a mouse model of chronic PA lung infection and suppression of Th17?mediated neutrophil recruitment in exogenous SOCS3 transfer in vitro Mol Med Rep, 2017-05-25;0(0):. 2017-05-25 [PMID: 28560450] (Mouse)		Mouse
Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth. Proc Natl Acad Sci U S A, 2012-12-31;110(3):972-7. 2012-12-31 [PMID: 23277563] (Human)		Human
Holenya P, Kitanovic I, Heigwer F, Wolfl S Microarray-based kinetic colorimetric detection for quantitative multiplex protein phosphorylation analysis. Proteomics, 2011-04-18;11(10):2129-33. 2011-04-18 [PMID: 21500346] (Human)		Human
Liu X, Yang P, Wang C, Li F, Kijlstra A IFN-alpha blocks IL-17 production by peripheral blood mononuclear cells in Behcet's disease. Rheumatology (Oxford), 2010-11-08;50(2):293-8. 2010-11-08 [PMID: 21059671] (Human)		Human

Array DYC4607B-2

• STAT3 Antibodies
• STAT3 Lysates
• STAT3 Proteins
• STAT3 ELISA