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Human IGF-II/IGF2 Quantikine ELISA Kit

 (7 Publications)
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Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

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Human IGF-II/IGF2 Quantikine ELISA Kit Summary

Background
The Quantikine® Human IGF-II Immunoassay is a 3.5 hour solid-phase ELISA designed to measure human IGF-II in cell culture supernates, serum, plasma, and urine. It contains E. coli-expressed recombinant human IGF-II and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human IGF-II showed linear curves that were parallel to the standard curves obt...ained using the Quantikine® kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human IGF-II.
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Specificity
Natural and recombinant human IGF-II.
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DG200.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IGF-II/IGF2 Quantikine ELISA Kit

  • C11orf43
  • chromosome 11 open reading frame 43
  • FLJ22066
  • FLJ44734
  • GRDF
  • IGF2
  • IGF-2
  • IGFII
  • IGF-II
  • insulin-like growth factor 2 (somatomedin A)
  • insulin-like growth factor II
  • insulin-like growth factor type 2
  • MSA
  • PEG2
  • PP9974
  • somatomedin-A

Background

Insulin-like growth factor (IGF)-I (also known as somatomedin C and somatomedin A) and IGF-II (multiplication stimulating activity or MSA) belong to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGF-I and IGF-II share approximately 70% sequence identity. Both IGF-I and IGF-II are expressed in many tissues and cell types and may have autocrine, paracrine and endocrine functions. Mature IGF-I and IGF-II are highly conserved between the human, bovine and porcine proteins (100% identity), and exhibit cross-species activity.

The IGFL (insulin-like growth factor-like) family includes four small (~11 kDa), probably secreted family members in humans and one in mouse. This family shares A and B chain cysteine motifs with the IGF superfamily, and has an additional cysteine motif within an uncleaved region corresponding to the C peptide of the IGF family.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for IGF-II/IGF2 (DG200)(7)

We have publications tested in 1 confirmed species: Human.


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Human
(7)
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Showing Publications 1 - 7 of 7.
Publications using DG200 Applications Species
JJ Tan, JP Guyette, K Miki, L Xiao, G Kaur, T Wu, L Zhu, KJ Hansen, KH Ling, DJ Milan, HC Ott Human iPS-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in vitro Nature Communications, 2021-08-17;12(1):4997. 2021-08-17 [PMID: 34404774] (Human) Human
N Requena-Oc, P Araos, M Flores, N García-Mar, D Silva-Peña, J Aranda, P Rivera, JJ Ruiz, A Serrano, FJ Pavón, J Suárez, F Rodríguez Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder Scientific Reports, 2021-08-02;11(1):15583. 2021-08-02 [PMID: 34341419] (Human) Human
N García-Mar, N Pizarro, FJ Pavón, M Martínez-H, M Flores-Lóp, N Requena-Oc, P Araos, D Silva-Peña, J Suárez, LJ Santín, R de la Torr, F Rodríguez, A Serrano Potential association of plasma lysophosphatidic acid (LPA) species with cognitive impairment in abstinent alcohol use disorders outpatients Sci Rep, 2020-10-13;10(1):17163. 2020-10-13 [PMID: 33051508] (Human) Human
T Manabe, H Yasuda, H Terai, H Kagiwada, J Hamamoto, T Ebisudani, K Kobayashi, K Masuzawa, S Ikemura, I Kawada, Y Hayashi, K Fukui, K Horimoto, K Fukunaga, K Soejima IGF2 autocrine-mediated IGF1R activation is a clinically relevant mechanism of osimertinib resistance in lung cancer Mol. Cancer Res., 2020-01-15;0(0):. 2020-01-15 [PMID: 31941753] (Human) Human
A Federico, M Dallio, M Masarone, AG Gravina, R Di Sarno, C Tuccillo, V Cossiga, S Lama, P Stiuso, F Morisco, M Persico, C Loguercio Evaluation of the Effect Derived from Silybin with Vitamin D and Vitamin E Administration on Clinical, Metabolic, Endothelial Dysfunction, Oxidative Stress Parameters, and Serological Worsening Markers in Nonalcoholic Fatty Liver Disease Patients Oxid Med Cell Longev, 2019;2019(0):8742075. 2019 [PMID: 31737175] (Human) Human
N Dai, F Ji, J Wright, L Minichiell, RI Sadreyev, J Avruch IGF2 mRNA binding protein-2 is a tumor promoter that drives cancer proliferation through its client mRNAs IGF2 and HMGA1 Elife, 2017-07-28;6(0):. 2017-07-28 [PMID: 28753127] (Human) Human
Howard H Bailey Phase IIa, randomized placebo-controlled trial of single high dose cholecalciferol (vitamin D3) and daily Genistein (G-2535) versus double placebo in men with early stage prostate cancer undergoing prostatectomy Am J Clin Exp Urol, 2016-09-20;4(2):17-27. 2016-09-20 [PMID: 27766277] (Human) Human

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