Human IGF-I R/IGF1R DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IGF-I receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha and two beta subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The alpha subunit of IGF-I receptor is extracellular while the beta subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The IGF-I receptor is highly expressed in all cell types and tissues.

IGF-II R is a type I transmembrane glycoprotein that contains a 2,264 amino acid (aa) extracellular region, a 23 aa transmembrane segment segment and a 124 aa cytoplasmic tail. IGF-II R regulates many diverse biological functions that range from intracellular trafficking to the internalization of extracellular factors and modulation of cellular responses. It delivers newly synthesized M6P-tagged lysosomal enzymes from the trans-golgi network to endosomes, and facilitates the clearance of extracellular lysosomal and matrix degrading enzymes by internalization into clathrin-coated vesicles and delivery into endosomes. With respect to IGF-II biology, It would appear that IGF-II R is principally a regulator of local IGF-II levels, targeting IGF-II for destruction in lysosomes.

The heterotetrameric receptors for insulin (INS R) and IGF-I (IGF-I R) are receptor tyrosine kinases that consist of two ligandbinding alpha subunits and two beta subunits. Ligand binding induces autophosphorylation on multiple tyrosine residues of beta subunits. Phosphorylation of Tyr1162 and 1163 on INS R and Tyr1135 and 1136 on IGF-I R stimulates intrinsic kinase activity.

We have publications tested in 2 confirmed species: Human, Complex Species Category.

Showing Publications 1 - 6 of 6.

Publications using DY391	Applications	Species
A Harangu?, R Lajos, L Budisan, O Zanoaga, C Ciocan, C Bica, R Pirlog, I Simon, M Simon, C Braicu, I Berindan-N Identification of Potential microRNA Panels for Male Non-Small Cell Lung Cancer Identification Using Microarray Datasets and Bioinformatics Methods Journal of personalized medicine, 2022-12-13;12(12):. 2022-12-13 [PMID: 36556276] (Human)		Human
G Vaniotis, S Moffett, T Sulea, N Wang, SM Elahi, E Lessard, J Baardsnes, S Perrino, Y Durocher, J Frystyk, B Massie, P Brodt Enhanced anti-metastatic bioactivity of an IGF-TRAP re-engineered to improve physicochemical properties Sci Rep, 2018-11-26;8(1):17361. 2018-11-26 [PMID: 30478273] (Complex Species Category)		Complex Species Category
Fluhr H, Spratte J, Ehrhardt J, Steinmuller F, Licht P, Zygmunt M Heparin and low-molecular-weight heparins modulate the decidualization of human endometrial stromal cells. Fertil. Steril., 2009-12-03;93(8):2581-7. 2009-12-03 [PMID: 19962139] (Human)		Human
Pitteri SJ, JeBailey L, Faca VM, Thorpe JD, Silva MA, Ireton RC, Horton MB, Wang H, Pruitt LC, Zhang Q, Cheng KH, Urban N, Hanash SM, Dinulescu DM Integrated proteomic analysis of human cancer cells and plasma from tumor bearing mice for ovarian cancer biomarker discovery. PLoS ONE, 2009-11-19;4(11):e7916. 2009-11-19 [PMID: 19936259] (Human)		Human
Wang N, Fallavollita L, Nguyen L, Burnier J, Rafei M, Galipeau J, Yakar S, Brodt P Autologous bone marrow stromal cells genetically engineered to secrete an igf-I receptor decoy prevent the growth of liver metastases. Mol. Ther., 2009-04-14;17(7):1241-9. 2009-04-14 [PMID: 19367255] (Human)		Human
Shi S, Mercer S, Eckert GJ, Trippel SB Growth factor regulation of growth factors in articular chondrocytes. J. Biol. Chem., 2009-01-09;284(11):6697-704. 2009-01-09 [PMID: 19136669] (Human)		Human

Array DY391

• IGF-I R/IGF1R Antibodies
• IGF-I R/IGF1R ELISA Kits
• IGF-I R/IGF1R Lysate
• IGF-I R/IGF1R Proteins
• IGF-I R/IGF1R Proteins and Enzymes
• IGF-I R/IGF1R ELISAs