Human Dkk-3 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Members of the dickkopf-related protein family (Dkk-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. Dkk-3 and -4 also have one prokineticin domain. Dkk-1, -2, and -4 function as antagonists of canonical Wnt signaling by binding to LRP5/6, preventing interaction of LRP5/6 with Wnt-Frizzled complexes. Dkk-1, -2, and -4 also bind cell surface Kremen-1 or -2 and promote the internalization of LRP5/6. Antagonistic activity of Dkk-3 has not been demonstrated. Dkk proteins have distinct patterns of expression in adult and embryonic tissues and have a wide range of effects on tissue development and morphogenesis. The Dkk family also includes Soggy, which is homologous to Dkk-3 but not to the other family members. Soggy has not been shown to inhibit Wnt signaling, and its role in the pathway is unclear.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 7 of 7.

Publications using DY1118	Applications	Species
S Hong, KH Park, YE Lee, JE Lee, YM Kim, E Joo, I Cho Antibody microarray analysis of amniotic fluid proteomes in women with cervical insufficiency and short cervix, and their association with pregnancy latency length PLoS ONE, 2022-02-07;17(2):e0263586. 2022-02-07 [PMID: 35130326] (Human)		Human
A Piek, L Smit, N Suthahar, SJL Bakker, RA de Boer, HHW Silljé The emerging plasma biomarker Dickkopf-3 (DKK3) and its association with renal and cardiovascular disease in the general population Scientific Reports, 2021-04-21;11(1):8642. 2021-04-21 [PMID: 33883651] (Human)		Human
XC Nie, F He, C Lan, JM Niu, P Xia Combined Serum DKK3 and Circulating CD133 Cells as Prognostic Biomarkers for Ovarian Cancer Patients OncoTargets and Therapy, 2021-01-14;14(0):427-434. 2021-01-14 [PMID: 33488097] (Human)		Human
EZ Hoseth, F Krull, I Dieset, RH Mørch, S Hope, ES Gardsjord, NE Steen, I Melle, HR Brattbakk, VM Steen, P Aukrust, S Djurovic, OA Andreassen, T Ueland Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder Transl Psychiatry, 2018-03-06;8(1):55. 2018-03-06 [PMID: 29507296] (Human)		Human
Fung , Kim Y C, Tabor , Bruce, Buckley , Michael, Priebe , Ilka K, Purins , Leanne, Pompeia , Celine, Brierley , Gemma V, Lockett , Trevor, Gibbs , Peter, Tie , Jeanne, McMurrick , Paul, Moore , James, Ruszkiewicz , Andrew, Nice , Edouard, Adams , Timothy, Burgess , Antony, Cosgrove , Leah J Blood-based protein biomarker panel for the detection of colorectal cancer. PLoS ONE, 2015-03-20;10(3):e0120425. 2015-03-20 [PMID: 25793510] (Human)		Human
Wang W, Zhu W, Xu XY The clinicopathological significance of REIC expression in colorectal carcinomas. Histol. Histopathol., 2012-06-01;27(6):735-43. 2012-06-01 [PMID: 22473694] (Human)		Human
Pitteri SJ, JeBailey L, Faca VM, Thorpe JD, Silva MA, Ireton RC, Horton MB, Wang H, Pruitt LC, Zhang Q, Cheng KH, Urban N, Hanash SM, Dinulescu DM Integrated proteomic analysis of human cancer cells and plasma from tumor bearing mice for ovarian cancer biomarker discovery. PLoS ONE, 2009-11-19;4(11):e7916. 2009-11-19 [PMID: 19936259] (Human)		Human

Array DY1118

• Dkk-3 Antibodies
• Dkk-3 Antibody Pairs
• Dkk-3 ELISA Kit
• Dkk-3 Lysates
• Dkk-3 Protein
• Dkk-3 Proteins and Enzyme
• Dkk-3 ELISA