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Human Complement Factor D Quantikine ELISA Kit

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Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

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Human Complement Factor D Quantikine ELISA Kit Summary

Background
The Quantikine Human Complement Factor D Immunoassay is a 3.5 hour sandwich ELISA designed to measure human Complement Factor D in cell culture supernates, serum, plasma, and urine. It contains NS0-expressed recombinant human Complement Factor D and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human Complement Factor D showed linear curves th...at were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human Complement Factor D.
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Specificity
Natural and recombinant human Complement Factor D
Source
N/A
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
CFD

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DFD00.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Complement Factor D Quantikine ELISA Kit

  • Adipsin
  • ADN
  • ADNcomplement factor D
  • AMBP-1
  • C3 convertase activator
  • CFD
  • complement factor D (adipsin)
  • complement factor D preproprotein
  • Complement Factor D
  • D component of complement (adipsin)
  • DF
  • EC 3.4.21
  • EC 3.4.21.46
  • PFD
  • Properdin factor DADIPSIN

Background

Complement Factor D, also known as adipsin, is a serine protease that catalyzes the initial proteolytic step in the alternative pathway of complement. It is an exceptionally specific protease and the only known protein substrate is factor B in complex with C3.3 Factor D protease activity is regulated by reversible conformational changes, which differs from the majority of serine proteases whose regulation involves either activation by processing of the zymogens or inactivation by binding of the inhibitors.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Complement Factor D/Adipsin (DFD00)(5)

We have publications tested in 1 confirmed species: Human.


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Human
(5)
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Showing Publications 1 - 5 of 5.
Publications using DFD00 Applications Species
Dumitrescu, G;Antovic, J;Soutari, N;Gran, C;Antovic, A;Al-Abani, K;Grip, J;Rooyackers, O;Taxiarchis, A; The role of complement and extracellular vesicles in the development of pulmonary embolism in severe COVID-19 cases PloS one 2024-08-23 [PMID: 39178205] (Human) Human
M Milek, Y Moulla, M Kern, C Stroh, A Dietrich, MR Schön, D Gärtner, T Lohmann, M Dressler, P Kovacs, M Stumvoll, M Blüher, E Guiu-Jurad Adipsin Serum Concentrations and Adipose Tissue Expression in People with Obesity and Type 2 Diabetes International Journal of Molecular Sciences, 2022-02-17;23(4):. 2022-02-17 [PMID: 35216336] (Human) Human
AM Risitano, AG Kulasekara, JW Lee, JP Maciejewsk, R Notaro, R Brodsky, M Huang, M Geffner, P Browett Danicopan: an oral complement factor D inhibitor for paroxysmal nocturnal hemoglobinuria Haematologica, 2021-12-01;0(0):0. 2021-12-01 [PMID: 33121236] (Human) Human
Small-molecule Factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome Haematologica, 2016-11-03;0(0):. 2016-11-03 [PMID: 27810992] (Human) Human
Reynolds R, Hartnett ME, Atkinson JP, Giclas PC, Rosner B, Seddon JM Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes. Invest. Ophthalmol. Vis. Sci., 2009-08-06;50(12):5818-27. 2009-08-06 [PMID: 19661236] (Human) Human

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Bioinformatics

Gene Symbol CFD