HSP40/DNAJB1 Antibody (2A7.H6)

Human Hsp40/DnaJ proteins comprise a large protein family, members of which feature the J domain (named after the bacterial DnaJ protein) (1). The J-domain spans the first 75 N-terminal amino acids and is separated from the C-terminal by a glycine/phenylalanine-rich domain (2). There are two main types of Hsp40; type 1 DNAJ proteins including HDJ2 and yeast YdjI; type II includes yeast Sis1 and human Hdj1. Whereas type I possesses a zinc finger domain which helps in the function of protein folding. (3, 4), type II does not. Members of the Hsp40/DnaJ family play diverse roles in many cellular processes, such as folding, translocation, degradation and assembly of multi-protein complexes. Hsp40 stimulates the ATPase activity of Hsp70 which in turn causes conformational changes of the unfolded proteins (5, 6). The Hsp40-Hsp70-unfolded protein complex further binds to co-chaperones Hip, Hop and HSP90 which leads to protein folding, or components of protein degradation machinery CHIP and BAG-1 (7).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	WB	Yeast	08/18/2017	View Summary Application Western Blot Sample Tested whole cell lysate Species Yeast Lot 0811 Comments Comments 4-12% Bis-Tris gel, 30ug of protein. Incubated o/n at 4C 1:1000 in milk.

Array NBP1-22416

• HSP40/DNAJB1 Antibodies
• HSP40/DNAJB1 ELISA Kits
• HSP40/DNAJB1 Lysate
• HSP40/DNAJB1 Protein
• HSP40/DNAJB1 Proteins and Enzyme