HSP27 [p Ser78, p Ser82, p Ser82] Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Heat shock proteins (HSPs) are a family of highly conserved stress response proteins. Heat shock proteins function primarily as molecular chaperones by facilitating the folding of other cellular proteins, preventing protein aggregation or targeting improperly folded proteins to specific degradative pathways. HSPs are typically expressed at low levels under normal physiological conditions but are dramatically up-regulated in response to cellular stress. Elevated levels of HSPs have been observed in association with ischemia/reperfusion, cancer, and chronic heart failure. HSP27 is a member of the small heat shock protein family, which also includes HSP25 and the alpha -crystallins. HSP27 forms a large oligomer and the extent of phosphorylation plays a role in determining specific functions. HSP27 also functions as an anti-apoptotic molecule, regulating apoptosis through direct interaction with key components of the apoptotic pathway. HSP27 binds and sequesters cytochrome c released from the mitochondria in response to an apoptotic stimulus. This prevents the proper assembly of the apoptosome and subsequently, the activation of procaspase-9 and procaspase-3.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Flow Cytometry, Western Blot.

Showing Publications 1 - 4 of 4.

Publications using AF2314	Applications	Species
Kennedy, KE;Kerlero de Rosbo, N;Uccelli, A;Cellerino, M;Ivaldi, F;Contini, P;De Palma, R;Harbo, HF;Berge, T;Bos, SD;Høgestøl, EA;Brune-Ingebretsen, S;de Rodez Benavent, SA;Paul, F;Brandt, AU;Bäcker-Koduah, P;Behrens, J;Kuchling, J;Asseyer, S;Scheel, M;Chien, C;Zimmermann, H;Motamedi, S;Kauer-Bonin, J;Saez-Rodriguez, J;Rinas, M;Alexopoulos, LG;Andorra, M;Llufriu, S;Saiz, A;Blanco, Y;Martinez-Heras, E;Solana, E;Pulido-Valdeolivas, I;Martinez-Lapiscina, EH;Garcia-Ojalvo, J;Villoslada, P; Multiscale networks in multiple sclerosis PLoS computational biology 2024-02-01 [PMID: 38329927] (Flow Cytometry, Human)	Flow Cytometry	Human
Agnes Schröder, Kathrin Wagner, Fabian Cieplik, Gerrit Spanier, Peter Proff, Christian Kirschneck Einfluss der Phosphorylierung des Hitzeschockproteins 27 auf das Expressionsprofil von parodontalen Ligamentfibroblasten bei mechanischer Belastung Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie 4/1/2023 [PMID: 35445818]
J Lee, JS Roberts, KR Atanasova, N Chowdhury, Ö Yilmaz A Novel Kinase Function of a Nucleoside-diphosphate-kinase Homolog in P. gingivalis is Critical in Subversion of Host Cell Apoptosis by Targeting Heat-Shock Protein 27 Cell. Microbiol., 2018-02-07;0(0):. 2018-02-07 [PMID: 29359393] (Western Blot, Human)	Western Blot	Human
Lin , Shih-Pei, Lee , Yi-Ting, Wang , Jir-You, Miller , Stephani, Chiou , Shih-Hwa, Hung , Mien-Chi, Hung , Shih-Chi Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27. PLoS ONE, 2012-11-20;7(11):e49605. 2012-11-20 [PMID: 23185379] (Western Blot, Human)	Western Blot	Human

Array AF2314

• HSP27 Antibodies
• HSP27 Antibody Pair
• HSP27 ELISA Kits
• HSP27 Lysate
• HSP27 Proteins
• HSP27 Proteins and Enzyme
• HSP27 ELISAs