hnRNP M1-M4 Antibody

Proteins that directly bind to nascent RNA polymerase II transcripts, the heterogenous nuclear ribonucleoproteins (hnRNPs), play an important role in both transcript-specific packaging and alternative splicing of pre-mRNAs. A group of abundant hnRNPs, the M1-M4 proteins, appear as a cluster of four proteins. The M proteins are pre-mRNA binding proteins in vivo, and they bind avidly to poly (G) and poly (U) RNA homopolymers in vitro. M proteins are members of the ribonucleoprotein consensus sequence family of RNA-binding proteins with greatest similarity to a hypothetical RNA-binding protein from Saccharomyces cerevisiae. The M proteins also possess an unusual hexapeptide-repeat region rich in methionine and arginine residues (MR repeat motif) that resembles a repeat in the 64kDa subunit of cleavage stimulation factor, which is involved in 3'-end maturation of pre-mRNAs. Proteins immunologically related to M exist in divergent eukaryotes ranging from human to yeast.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ICC/IF.

Showing Publications 1 - 2 of 2.

Publications using NBP1-84555	Applications	Species
Varjak M, Saul S, Arike L et al. Magnetic Fractionation and Proteomic Dissection of Cellular Organelles Occupied by the Late Replication Complexes of Semliki Forest Virus. J Virol 2013-09-01 [PMID: 23864636]
Birladeanu A, Rogalska M, Potiri M et al. The IQGAP1-hnRNPM interaction links tumour-promoting alternative splicing to heat-induced signals bioRxiv 2020-05-14 (ICC/IF, Human)	ICC/IF	Human

Array NBP1-84555

• hnRNP M1-M4 Antibodies
• hnRNP M1-M4 Protein