HNF-4 alpha/NR2A1 Antibody

The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Primate.

We have publications tested in 2 applications: ChIP, WB.

Showing Publications 1 - 6 of 6.

Publications using NB100-1783	Applications	Species
Damcott CM, Hoppman N, Ott SH et al. Polymorphisms in both promoters of hepatocyte nuclear factor 4-alpha are associated with type 2 diabetes in the Amish. Diabetes 2004-12-01 [PMID: 15561969]
Clark A, Saade M, Vemireddy V et al. HNF4? mediated QPRT expression in the kidney facilitates resilience against acute kidney injury bioRxiv 2023-05-25 (ChIP, Mouse)	ChIP	Mouse
Clark AJ, Saade MC, Vemireddy V et al. Hepatocyte nuclear factor 4? mediated quinolinate phosphoribosylltransferase (QPRT) expression in the kidney facilitates resilience against acute kidney injury Kidney international 2023-09-30 [PMID: 37783445]
Wang SH, Yeh SH, Lin WH, Yeh KH, Yuan Q, Xia NS, Chen DS, Chen PJ. Estrogen Receptor alpha Represses Transcription of HBV Genes via Interaction With Hepatocyte Nuclear Factor 4alpha. Gastroenterology;142(4):989-998. 2012-04-01 [PMID: 22240483] (WB, Human)	WB	Human
Huang J, Levitsky LL, Rhoads DB et al. Novel P2 promoter-derived HNF4alpha isoforms with different N-terminus generated by alternate exon insertion. Exp Cell Res 2009-04-15 [PMID: 19353766]
Huang J, Karakucuk V, Levitsky LL et al. Expression of HNF4alpha variants in pancreatic islets and Ins-1 beta cells. Diabetes Metab Res Rev 2008-10-01 [PMID: 18561282] (WB, Primate)	WB	Primate

Images	Ratings	Applications	Species	Date	Details
	1 reviewed by: Marisa Ferreira	ICC	Mouse	06/29/2023	View Summary Application Immunocytochemistry Sample Tested Mouse Liver Tissue Species Mouse Lot P1 Comments Comments ***Bio-Techne Response: Thank you for reviewing our product. We are sorry to hear that this product did not perform as expected. We have been in touch with the customer to resolve this issue according to our Product Guarantee and to the customer’s satisfaction.***

Array NB100-1783

• HNF-4 alpha/NR2A1 Antibodies
• HNF-4 alpha/NR2A1 Lysates
• HNF-4 alpha/NR2A1 Proteins