HGS Antibody

HRS plays an esssential role in endosome membrane invagination and formation of multivesicular bodies (MVBs). It is required during gastrulation and appears to regulate early embryonic signaling pathways. HRS inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated active receptor, possibly by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 4 of 4.

Publications using NB100-55249	Applications	Species
Rose Willett, José A. Martina, James P. Zewe, Rachel Wills, Gerald R. V. Hammond, Rosa Puertollano TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes Nature Communications 2017-11-17 [PMID: 29146937]
Yim YI, Park BC, Yadavalli R et al. The multivesicular body is the major internal site of prion conversion J. Cell. Sci. 2015-02-06 [PMID: 25663703] (WB, Mouse)	WB	Mouse
Schroeder B, Srivatsan S, Shaw A et al. CIN85 phosphorylation is essential for EGFR ubiquitination and sorting into multivesicular bodies. Mol Biol Cell 2012-09-01 [PMID: 22833562]
Buchanan SM, Schalm SS, Maniatis T et al. Proteolytic processing of protocadherin proteins requires endocytosis. Proc Natl Acad Sci U S A 2010-10-01 [PMID: 20876099]

Array NB100-55249

• HGS Antibodies
• HGS Lysate
• HGS Proteins