GSTA1 Antibody (2F7)

This product is produced by and distributed for Abnova, a company based in Taiwan.

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 3 of 3.

Publications using H00002938-M01	Applications	Species
Woolston CM, Al-Attar A, Storr SJ et al. Redox Protein Expression Predicts Radiotherapeutic Response in Early-Stage Invasive Breast Cancer Patients. Int J Radiat Oncol Biol Phys. 2011-02-05 [PMID: 21300479]
Cramer DW, O'Rourke DJ, Vitonis AF et al. CA125 immune complexes in ovarian cancer patients with low CA125 concentrations Clin Chem 2010-12-01 [PMID: 20943848] (Human)		Human
Pasello M, Michelacci F, Scionti I et al. Overcoming Glutathione S-Transferase P1-Related Cisplatin Resistance in Osteosarcoma. Cancer Res;68(16):6661-6668. 2008-01-01 [PMID: 18701490]

Array H00002938-M01

• GSTA1 Antibodies
• GSTA1 ELISA Kits
• GSTA1 Lysate
• GSTA1 Proteins