GSTA1 Products

Description

GSTA1 is glutathione S-transferase which are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.

Bioinformatics

Entrez	2938 Human
Uniprot	AAH53578 Human NM_145740 Human NP_665683 Human NP_665683.1 Human P08263 Human
Product By Gene ID	2938
Alternate Names	EC 2.5.1.18 glutathione S-alkyltransferase A1 glutathione S-aryltransferase A1 glutathione S-transferase 2 glutathione S-transferase A1 glutathione S-transferase alpha 1 glutathione S-transferase Ha subunit 1 GST class-alpha member 1 GST HA subunit 1 GST, class alpha, 1 GST2 GSTA1-1 GST-epsilon GTH1 MGC131939 S-(hydroxyalkyl)glutathione lyase A1