GRP78/HSPA5 Antibody (3C5-1A4)

GRP78 is a ubiquitously expressed, 78-kDa glucose-regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the proper folding and assembly of nascent protein and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5' nontranslated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed (1). GRP78 is also critical for maintenance of cell homeostasis and the prevention of apoptosis (2). Luo et al. have provided findings that suggest GRP78 is essential for embryonic cell growth and pluripotent cell survival (3).In terms of diseases, GRP78 has been shown to be a reliable biomarker of hypoglycemia, to serve a neuroprotective function in neurons exposed to glutamate and oxidative stress (4), and its protein levels are reduced in the brains of Alzheimer's patients (5). Also, the induction of the GRP78 protein that results in severe glucose and oxygen deprivation could possible lead to drug resistance to anti-tumor drugs (6, 7).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	ICC	Human	05/03/2020	View Summary Application Immunocytochemistry Sample Tested Human breast cancer cell line SKBR3 and this product Species Human Lot 140501
Enlarge	4 reviewed by: Verified Customer	WB	Mouse	12/27/2019	View Summary Application Western Blot Sample Tested 4T1 cells whole cell lysate Species Mouse Lot 140501
Enlarge	5 reviewed by: Verified Customer	WB	Human	10/28/2018	View Summary Application Western Blot Sample Tested breast cancer MCF7 cells,HCC827 human non-small cell lung cancer cell line Species Human Lot 140501

Array NBP2-59692

• GRP78/HSPA5 Antibodies
• GRP78/HSPA5 ELISA Kits
• GRP78/HSPA5 Lysate
• GRP78/HSPA5 Proteins