Independent Antibodies: Immunohistochemistry-Paraffin: GRK1 Antibody [NBP2-55226] - Staining of human colon, eye, retina, liver and lymph node using Anti-GRK1 antibody NBP2-55226 (A) shows similar protein ...read more
Immunohistochemistry-Paraffin: GRK1 Antibody [NBP2-55226] - Staining of human eye, retina.
Immunohistochemistry-Paraffin: GRK1 Antibody [NBP2-55226] - Staining of human lymph node.
Immunohistochemistry-Paraffin: GRK1 Antibody [NBP2-55226] - Staining of human liver.
Immunohistochemistry-Paraffin: GRK1 Antibody [NBP2-55226] - Staining of human colon.
This antibody was developed against a recombinant protein corresponding to the following amino acid sequence: MDFGSLETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFESVCLEQPIGKKLFQQFLQSA
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GRK1
Purity
Affinity purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.
Use in Monkey reported in scientific literature (PMID:35024589) Mouse 85%, Rat 82%.
Packaging, Storage & Formulations
Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Affinity purified
Alternate Names for GRK1 Antibody
G protein-coupled receptor kinase 1rhodopsin kinase
GPRK1
GRK1
RHOK
RHOKEC 2.7.11
RKEC 2.7.11.14
Background
The sensation of sight is the result of a cascade of events starting with the interaction of photoactivated rhodopsin with a protein called transducin. Rhodopsin kinase is a G-protein-coupled Ser/Thr kinase, also known as GRK1, which is a key element in the regulation of this cascade. Following phosphorylation by GRK1, arrestin is recruited to phospho-rhodopsin quenching its phototransductive activity by preventing further interaction with transducin. By breaking the cycle of phototransduction, GRK1 plays an important role in the restoration of the system for subsequent visual events.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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