Recombinant Human Grancalcin His Protein

GCA, also known as Grancalcin, is calcium-binding protein that is especially abundant in human neutrophils. It belongs to the penta EF-hand (PEF) subfamily of EF-hand proteins, which also comprises calpain, sorcin, peflin, and ALG-2. This protein undergoes important conformational changes upon binding of calcium, which subsequently exposes hydrophobic amino acid residues, which direct the protein to hydrophobic surfaces. It interacts with L-plastin, a protein known to have actin bundling activity, which suggests that GCA may play a role in the regulation of neutrophils adhesion. Recombinant human GCA protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Showing Publications 1 - 2 of 2.

Publications using NBP1-50967	Applications	Species
Nan-Yu Zou, Ran Liu, Mei Huang, Yu-Rui Jiao, Jie Wei, Yangzi Jiang, Wen-Zhen He, Min Huang, Yi-Li Xu, Ling Liu, Yu-Chen Sun, Mi Yang, Qi Guo, Yan Huang, Tian Su, Ye Xiao, Wei-Shan Wang, Chao Zeng, Guang-Hua Lei, Xiang-Hang Luo, Chang-Jun Li Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing Bone Research 2024-01-25 [PMID: 38267422]
Li CJ, Xiao Y, Sun YC Et al. Senescent immune cells release grancalcin to promote skeletal aging Cell metabolism 2021-10-05 [PMID: 34614408]

Array NBP1-50967

• Grancalcin Antibodies
• Grancalcin Lysate
• Grancalcin Proteins