| Applications | Flow |
| Clone | 784808 |
| Clonality | Monoclonal |
| Host | Rat |
| Conjugate | Phycoerythrin |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse GPVI Gly24-Lys265 Accession # P0C191 |
| Specificity | Detects mouse GPVI in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human GPVI is observed. |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Host | Rat |
| Gene | GP6 |
| Purity | Protein A or G purified from hybridoma culture supernatant |
| Purity Statement | Protein A or G purified from hybridoma culture supernatant |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
| Storage | Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light. |
| Buffer | Supplied in a saline solution containing BSA and Sodium Azide. |
| Preservative | Sodium Azide |
| Purity | Protein A or G purified from hybridoma culture supernatant |
GPVI (Platelet Glycoprotein VI), also known as Glycoprotein 5, is a member of the Ig superfamily. It is found on platelets and megakaryocytes, and serves as the main collagen receptor on platelets. Following exposure to subendothelial connective tissue, GPVI binds to a Gly-Pro-(hydroxy)Pro motif on collagen and generates a noncovalent membrane signaling complex with FcR gamma -chain. This interaction is stabilized by Integrin alpha 2 beta 1, followed by activation of PLC gamma 2 with clot initiation. Mature mouse GPVI is a 292 amino acid (aa) type I transmembrane protein. It possesses a 244 aa extracellular region (aa 22-265) that contains two C2-type Ig-like domains (aa 27-197)and two potential glycosylation sites, plus a 37 aa cytoplasmic tail (aa 287-313). There is one potential splice form that shows a deletion of aa 224-240. Over aa 24-265, mouse GPVI shares 70% and 86% aa identity with human and rat GPVI, respectively.
![GPVI Antibody (784808) [Phycoerythrin]](/sites/all/modules/enterprise-tech/et_datasheets/images/novus_guarantee.png "GPVI Antibody (784808) [Phycoerythrin]")
The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.
| Gene Symbol | GP6 |
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