gp130/CD130 Antibody (28126) [Phycoerythrin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Glycoprotein 130 (gp130; also known as IL-6 signal transducer, IL-6 receptor beta, oncostatin-M alpha subunit) is a ubiquitously expressed, 130 kDa type I transmembrane glycoprotein and member of the type II subfamily, type I cytokine receptor family. Functionally, it is responsible for transduction of the IL-6 signal across the plasma membrane (1). Rat gp130 is synthesized as a 918 amino acid (aa) precursor with a 22 aa signal sequence, a 596 aa extracellular domain (ECD), a 22 aa transmembrane region, and a 278 aa cytoplasmic tail. Eleven potential N-linked glycosylation sites are found within the rat gp130 ECD (1). The ECD also contains an N terminal immunoglobulin (Ig)-like C2-type domain, followed by the cytokine receptor homology region (CHR) which is made up of two fibronectin type III-like domains and a WSXWS motif, and three additional fibronectin type III-like domains (2). The domains in the CHR are the structural hallmarks of the hematopoietic cytokine receptor family (2). Human gp130 shares 73% and 79% aa sequence identity with mouse and rat gp130, respectively. Gp130 serves as the signal transducing receptor subunit for the IL-6-type cytokines consisting of interleukin (IL)-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), new neurotrophin factor-1 (NNT-1), IL-27, cardiotrophin-1 (CT-1), and cardiotrophin like cytokine (CLC) (2 - 5). These cytokines are involved in a variety of functions including the modulation of inflammatory and immune responses, heart development, fertility, and many other activities (2).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Flow Cytometry, ICC.

Showing Publications 1 - 6 of 6.

Publications using FAB228P	Applications	Species
H Suzuki, S Mitsunaga, M Ikeda, T Aoyama, K Yoshizawa, M Yamaguchi, M Suzuki, M Narita, T Kawasaki, A Ochiai Interleukin 6/gp130 axis promotes neural invasion in pancreatic cancer Cancer Medicine, 2022-05-16;0(0):. 2022-05-16 [PMID: 35578571] (Flow Cytometry, Human)	Flow Cytometry	Human
MH Kubala, V Punj, VR Placencio-, H Fang, GE Fernandez, R Sposto, YA DeClerck Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer Cell Rep, 2018-11-20;25(8):2177-2191.e7. 2018-11-20 [PMID: 30463014] (Flow Cytometry, Human)	Flow Cytometry	Human
Ray S, Ju X, Sun H, Finnerty C, Herndon D, Brasier A The IL-6 trans-signaling-STAT3 pathway mediates ECM and cellular proliferation in fibroblasts from hypertrophic scar. J Invest Dermatol, 2013-01-10;133(5):1212-20. 2013-01-10 [PMID: 23303450] (Flow Cytometry, Human)	Flow Cytometry	Human
Cocco C, Di Carlo E, Zupo S Complementary IL-23 and IL-27 anti-tumor activities cause strong inhibition of human follicular and diffuse large B-cell lymphoma growth in vivo. Leukemia, 2011-12-23;26(6):1365-74. 2011-12-23 [PMID: 22193967] (Flow Cytometry, Human)	Flow Cytometry	Human
Larsen JV, Hansen M, Moller B, Madsen P, Scheller J, Nielsen M, Petersen CM Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimer. Mol. Cell. Biol., 2010-06-28;17(0):4175. 2010-06-28 [PMID: 20584990] (Flow Cytometry, Human)	Flow Cytometry	Human
Marino M, Scuderi F, Provenzano C, Scheller J, Rose-John S, Bartoccioni E IL-6 regulates MCP-1, ICAM-1 and IL-6 expression in human myoblasts. J. Neuroimmunol., 2008-04-08;196(1):41-8. 2008-04-08 [PMID: 18400310] (ICC, Human)	ICC	Human

Array FAB228P

• gp130/CD130 Antibodies
• gp130/CD130 Antibody Pair
• gp130/CD130 ELISA Kits
• gp130/CD130 Lysate
• gp130/CD130 Protein
• gp130/CD130 ELISAs
• gp130/CD130 Proteins and Enzymes