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gp130/CD130 Antibody (125623) [Allophycocyanin]

 (6 Publications)
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Mouse splenocytes were stained with Rat Anti-Mouse CD3 PE-conjugated Monoclonal Antibody (Catalog # FAB4841P) and either (A) Rat Anti-Mouse gp130 APC-conjugated Monoclonal Antibody (Catalog # FAB4681A) or (B) Rat IgG2AAllophycocyanin Isotype Control (Catalog # IC006A). View our protocol for Staining Membrane-associated Proteins.
Mouse splenocytes were stained with Rat Anti-Mouse CD3 PE-conjugated Monoclonal Antibody (Catalog # FAB4841P) and either (A) Rat Anti-Mouse gp130 APC-conjugated Monoclonal Antibody (Catalog # FAB4681A) or (B) Rat ...read more

Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow
Clone
125623
Clonality
Monoclonal
Host
Rat
Conjugate
Allophycocyanin

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB4681U-100UG
Alexa Fluor 405
FAB4681V-100UG
Alexa Fluor 488
FAB4681G-100UG
Alexa Fluor 532
FAB4681X
Alexa Fluor 594
FAB4681T-100UG
Alexa Fluor 647
FAB4681R-100UG
Alexa Fluor 700
FAB4681N-100UG
Alexa Fluor 750
FAB4681S-100UG
Allophycocyanin
FAB4681A-025UG
Allophycocyanin/Cy7
FAB4681APCCY7
Biotin
BAM4681
CoraFluor 1
FAB4681CL1
DyLight 350
FAB4681D
DyLight 405
FAB4681E
DyLight 488
FAB4681K
DyLight 550
FAB4681L
DyLight 594
FAB4681M
DyLight 650
FAB4681W
DyLight 680
FAB4681Y
DyLight 755
FAB4681Z
FITC
FAB4681F
HRP
FAB4681H
Janelia Fluor 525
FAB4681JF525
Janelia Fluor 549
FAB4681I
Janelia Fluor 646
FAB4681J
Janelia Fluor 669
FAB4681JF669
PE/Atto594
FAB4681PEATT594
PE/Cy5.5
FAB4681PECY55
PE/Cy7
FAB4681PECY7
PerCP
FAB4681C
Unconjugated
MAB4681
mFluor Violet 450 SE
FAB4681MFV450
mFluor Violet 500 SE
FAB4681MFV500
mFluor Violet 610 SE
FAB4681MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB4681
Carrier Free
MAB4681
Carrier Free
MAB4681-SP
Carrier Free
FAB4681V-100UG
Carrier Free
FAB4681U-100UG
Carrier Free
FAB4681T-100UG
Carrier Free
FAB4681S-100UG
Carrier Free
FAB4681R-100UG
Carrier Free
FAB4681N-100UG
Carrier Free
FAB4681G-100UG
Carrier Free
FAB4681A-025UG
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gp130/CD130 Antibody (125623) [Allophycocyanin] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse gp130
Gln23-Glu617 (predicted)
Accession # Q6PDI9
Specificity
Detects mouse gp130 in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human gp130 is observed.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
IL6ST
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.25-1 ug/10^6 cells
Publications
Read Publications using
FAB4681A in the following applications:

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for gp130/CD130 Antibody (125623) [Allophycocyanin]

  • CD130 antigen
  • CD130
  • CDw130
  • DKFZp564F053
  • gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form
  • gp130
  • IL-6 receptor subunit beta
  • IL-6R subunit beta
  • IL-6RB
  • IL-6R-beta
  • IL6ST
  • interleukin 6 signal transducer (gp130, oncostatin M receptor)
  • interleukin receptor beta chain
  • interleukin-6 receptor subunit beta
  • Interleukin-6 signal transducer
  • Membrane glycoprotein 130
  • membrane glycoprotein gp130
  • Oncostatin-M receptor subunit alpha

Background

Gp130, the common signal transducing receptor component shared by the functional receptor complexes of the IL-6 family of cytokines, belongs to the class I cytokine receptor family. Binding of IL-6 (IL-11) to either the membrane-anchored or soluble IL-6 R (IL-11 R) initiates the association of IL-6 R (IL-11 R) with gp130 which then undergoes homo-dimerization and signal transduction. With other IL-6 family cytokines, such as LIF and OSM, signal transduction is triggered by the hetero-dimerization of gp130 and LIF R or OSM R.

Gp130 is expressed in all organs examined. Soluble gp130, which apparently arises either from proteolytic cleavage of the membrane-bound receptor or from alternative splicing, has been detected in human serum. The in vivo functions of soluble gp130 are not clearly understood. In in vitro experiments, natural or recombinant soluble gp130 has been shown to have inhibitory effects on OSM and CNTF activities.

  1. Narazaki, M. et al. (1993) Blood 82:1120.
  2. Taga, T. and T. Kishimoto (1997) Annu. Rev. Immunol. 15:797.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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gp130/CD130
Antibody (125623) [Al ...
FAB4681A
gp130/CD130 Antibody (125623) [Allophycocyanin]
Species: Mu
Applications: Flow

Publications for gp130/CD130 Antibody (FAB4681A)(6)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Flow Cytometry.


Filter By Application
Flow Cytometry
(6)
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Mouse
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Showing Publications 1 - 6 of 6.
Publications using FAB4681A Applications Species
Gupta, D;Orehek, S;Turunen, J;O'Donovan, L;Gait, MJ;El-Andaloussi, S;Wood, MJA; Modulation of Pro-Inflammatory IL-6 Trans-Signaling Axis by Splice Switching Oligonucleotides as a Therapeutic Modality in Inflammation Cells 2023-09-15 [PMID: 37759507] (Flow Cytometry, Mouse) Flow Cytometry Mouse
H Nagashima, Y Okuyama, T Hayashi, N Ishii, T So TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development J Immunol, 2016-04-13;0(0):. 2016-04-13 [PMID: 27076680] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Pratama , Alvin, Srivastava , Monika, Williams , Naomi J, Papa , Ilenia, Lee , Sau K, Dinh , Xuyen T, Hutloff , Andreas, Jordan , Margaret, Zhao , Jimmy L, Casellas , Rafael, Athanasopoulos , Vicki, Vinuesa , Carola G MicroRNA-146a regulates ICOS-ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres. Nat Commun, 2015-03-06;6(0):6436. 2015-03-06 [PMID: 25743066] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Nagashima , Hiroyuki, Okuyama , Yuko, Asao , Atsuko, Kawabe , Takeshi, Yamaki , Satoshi, Nakano , Hiroyasu, Croft , Michael, Ishii , Naoto, So , Takanori The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6. Nat Immunol, 2014-03-30;15(5):449-56. 2014-03-30 [PMID: 24681564] (Flow Cytometry, Mouse) Flow Cytometry Mouse
IL-6 mediates the susceptibility of glycoprotein 130 hypermorphs to Toxoplasma gondii. J. Immunol., 2011-05-23;187(1):350-60. 2011-05-23 [PMID: 21606248] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Liao W, Lin JX, Wang L, Li P, Leonard WJ Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages. Nat. Immunol., 2011-04-24;12(6):551-9. 2011-04-24 [PMID: 21516110] (Flow Cytometry, Mouse) Flow Cytometry Mouse

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Bioinformatics

Gene Symbol IL6ST
Uniprot