GLI-2 Antibody - BSA Free

Gli2, also known as THP, is a transcription factor which binds DNA through zinc finger motifs. Belonging to the C2H2-Zinc finger type subclass of the Gli family, Gli2 is a mediator of Shh (sonic hedgehog) signaling, a pathway that is aberrantly activated in many types of cancers. Specifically, it has been found that the anti-apoptotic protein BCL-2 is up regulated by Gli2, leading to carcinogenesis. The protein encoded by the Gli2 gene localizes to the cytoplasm and activates patched (Drosophila homolog) gene expression, where it has been thought to play an important role during embryogenesis. Mutations in the Gli2 gene are found in various syndromes, including Pallister-Hall Syndrome, Greig cephalopolysyndactyly syndrome, and preaxial polydactyl type IV. Recently, the interaction between the hedgehog signaling pathway and Gli2 has been implicated in medullary thyroid carcinoma (PMID: 23410206).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 2 applications: IF/IHC, IHC-Fr.

Showing Publications 1 - 3 of 3.

Publications using NBP2-23602	Applications	Species
Chen J, Cheng NC, Boland JA Et al. Deletion of kif3a in CK19 positive cells leads to primary cilia loss, biliary cell proliferation and cystic liver lesions in TAA-treated mice Biochim Biophys Acta Mol Basis Dis 2022-01-01 [PMID: 34973373] (IF/IHC, Mouse) Details: Citation using the Alexa Fluor 647 version of this antibody.	IF/IHC	Mouse
Chakrabarti J, Holokai L, Syu L et al. Hedgehog signaling induces PD-L1 expression and tumor cell proliferation in gastric cancer. Oncotarget 2018-12-21 [PMID: 30647844]
Martinez JA, Kobayashi M, Krishnan A et al. Intrinsic facilitation of adult peripheral nerve regeneration by the Sonic hedgehog morphogen Exp. Neurol. 2015-07-22 [PMID: 26210874] (IHC-Fr, Rat)	IHC-Fr	Rat

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Verified Customer	IHC-P	Mouse	08/17/2021	View Summary Application Immunohistochemistry-Paraffin Sample Tested Breast cancer tissue Species Mouse Lot A-3 Comments Comments Citrate retrieval buffer

Array NBP2-23602

• GLI-2 Antibodies
• GLI-2 Lysate
• GLI-2 Proteins