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Gephyrin/GPHN Antibody (9D0B0)

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Western Blot: Gephyrin/GPHN Antibody (9D0B0) [NBP3-16472] - Western blot analysis of extracts of various cell lines, using Gephyrin/GPHN Rabbit mAb (NBP3-16472) at 1:1000 dilution. Secondary antibody: HRP Goat ...read more
Western Blot: Gephyrin/GPHN Antibody (9D0B0) [NBP3-16472] - Western blot analysis of extracts of various cell lines, using Gephyrin/GPHN Rabbit mAb (NBP3-16472) at 1:1000 dilution. Secondary antibody: HRP Goat ...read more

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB
Clone
9D0B0
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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Gephyrin/GPHN Antibody (9D0B0) Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Gephyrin/GPHN (NP_001019389). MATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKETLIDWCDEKELNLILTTGGTGFAPRDVTPEAT
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
GPHN
Purity
Affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500 - 1:1000

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS, 0.05% BSA, 50% glycerol, pH7.3
Preservative
0.02% Sodium Azide
Purity
Affinity purified

Alternate Names for Gephyrin/GPHN Antibody (9D0B0)

  • GEPH
  • Gephyrin
  • GPH
  • GPHN
  • GPHRYN
  • KIAA1385GPHGEPH

Background

The Gephyrin (GPHN) gene encodes a neuronal assembly protein that exists in isoform 1 (736 amino acids long, 79 kDA) or isoform 2 (769 amino acids in length, approximately 83 kDA). This protein anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton through high affinity binding to a receptor subunit domain and tublin dimers. The protein coded by GPHN is also necessary for molybdenum biosynthesis. The GPHN gene has been investigated in relation to many diseases such as leukemia, cervicitis, tuberculosis, alzheimer's disease, anorexia nervosa, huntington's disease, retinitis, and herpes zoster. The GPHN gene interacts with genes DYNLL1, PFN1, PRPF4, ENAH, and SLX4 to participate in pathways that regulate metabolism of vitamins and cofactors as well as molybdenum cofactor biosynthesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol GPHN