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FKBP25 Antibody (423325)

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Western blot shows lysates of Jurkat human acute T cell leukemia cell line, HeLa human cervical epithelial carcinoma cell line, MCF-7 human breast cancer cell line, and CHP-100 human neuroblastoma cell line. PVDF ...read more

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB
Clone
423325
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Formulations
Catalog# & Formulation Size Price

FKBP25 Antibody (423325) Summary

Immunogen
E. coli-derived recombinant human FKBP25
Ala2-Asp224
Accession # Q00688
Specificity
Detects endogenous human, mouse, and rat FKBP25 in Western blots. In Western blots, this antibody does not cross-react with recombinant human FKBP12, FKBP12.6, FKBP13, FKBP38, FKBP51, or FKBP52.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Rat
Gene
FKBP3
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FKBP25 Antibody (423325)

  • EC 5.2.1.8,25 kDa FK506-binding protein
  • FK506 binding protein 3, 25kDa
  • FK506-binding protein 3 (25kD)
  • FK506-binding protein 3
  • FKBP25
  • FKBP25,25 kDa FKBP
  • FKBP3
  • FKBP-3
  • Immunophilin FKBP25
  • peptidyl-prolyl cis-trans isomerase FKBP3
  • PPIase FKBP3
  • PPIase
  • rapamycin binding protein
  • Rapamycin-selective 25 kDa immunophilin
  • rotamase
  • T-cell

Background

FK506 binding protein, 25 kDa molecular weight (FKBP25), also called FKBP3, is a peptidyl-prolyl isomerase that catalyzes the transition between cis- and trans-proline residues critical for proper folding of proteins. The macrolide immunosuppressant Rapamycin is a potent inhibitor of FKBP25. FKBP25 is localized in the nucleus, where it alters the activity of histone deacetylases and transcription factors. It is found in many tissues, including brain, thymus, and spleen.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol FKBP3
Uniprot