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FGFR3 Antibody (136318) [Unconjugated]

 (4 Publications)
 (1 Review)
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Recombinant Human FGF R3 (IIIc) Fc Chimera (Catalog # 766-FR) inhibits Recombinant Human FGF acidic (Catalog # 232-FA) induced proliferation in the NR6R‑3T3 mouse fibroblast cell line in a dose-dependent manner (orange line) as measured by Resazurin (Catalog # AR002) . Inhibition of Recombinant Human FGF acidic (0.3 ng/mL) activity elicited by Recombinant Human FGF R3 (IIIc) Fc Chimera (6 ng/mL) is neutralized (green line) by increasing concentrations of Human FGF R3 Monoclonal Antibody (Catalog # MAB7661). The ND50 is typically 2.5-15 ng/mL in the presence of heparin (10 µg/mL).
Recombinant Human FGF R3 (IIIc) Fc Chimera (Catalog # 766-FR) inhibits Recombinant Human FGF acidic (Catalog # 232-FA) induced proliferation in the NR6R‑3T3 mouse fibroblast cell line in a dose-dependent manner ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, B/N
Clone
136318
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB7661-SP
Carrier Free
MAB7661-500
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FGFR3 Antibody (136318) [Unconjugated] Summary

Immunogen
Pool of NS0-derived recombinant human FGF R3 alpha (IIIb) and Sf21-derived FGF R3 alpha (IIIc)
Specificity
Detects the IIIb and IIIc isoforms of human FGF R3. It does not cross-react with mouse FGF R3 or with any isoforms of recombinant human (rh) FGF R1 or rhFGF R2.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
FGFR3
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Neutralization 2.5-15 ng/mL
  • Western Blot 1 ug/mL
Reviewed Applications
Read 1 Review rated 4
using
MAB7661 in the following applications:
Publications
Read Publications using
MAB7661 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FGFR3 Antibody (136318) [Unconjugated]

  • CD333
  • CEK
  • EC 2.7.10
  • FGF R3
  • FGFR3
  • fibroblast growth factor receptor 3
  • HSFGFR3EX
  • JTK4
  • JTK4thanatophoric dwarfism

Background

The extracellular domain of FGF R3 includes 3 Ig-like domains. A segment of the membrane proximal Ig-like domain can be encoded by two different exons resulting in (IIIb) or (IIIc) isoforms.


Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FGFR3 Antibody
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MAB7661
FGFR3 Antibody (136318) [Unconjugated]
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Publications for FGFR3 Antibody (MAB7661)(4)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IHC-Fr, Neutralization.


Filter By Application
IHC-Fr
(1)
Neutralization
(1)
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Human
(2)
All Species

Review for FGFR3 Antibody (MAB7661) (1) 41

Average Rating: 4
(Based on 1 review)
We have 1 review tested in 1 species: Human.

Reviews using MAB7661:
Filter by Applications
ICC
(1)
All Applications
Filter by Species
Human
(1)
All Species
Images Ratings Applications Species Date Details
Immunocytochemistry FGFR3 MAB7661
Enlarge 		4
reviewed by:
Natalie Erdmann
 ICC Human 01/28/2016
View

Summary

ApplicationImmunocytochemistry
Sample TestedKMS11, KMS18 and RPMI8226 (multiple myeloma) cell lines
SpeciesHuman
LotGHV021601A

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Recent Reviews

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5
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1
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Immunocytochemistry FGFR3 MAB7661
Enlarge
 Natalie Erdmann
01/28/2016
Application: ICC
Species: Human
read this review

Bioinformatics

Gene Symbol FGFR3