Fc gamma RIII (CD16) Antibody (245536) [Biotin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CD16 (also known as FcgRIII) is a CD designation that, in human, encompasses two related, but distinct Ig superfamily genes; CD16a and CD16b. Mature human CD16a is a 45-75 kDa type I transmembrane glycoprotein that is 238 amino acids (aa) in length. It contains a 192 aa extracellular region that possesses two Ig-like domains plus glycosylation that is critical to its function, and ends with a short 25 aa cytoplasmic domain. On the cell surface, CD16a complexes with FceRI and CD3 zeta . CD16a shows a restricted expression pattern, being found on immature thymocytes, placental trophoblast cells, CD56dim and cytokine-activated CD56+ NK cells, slan (sulfated NAcLac)-expressing dendritic cells, and CX3CR1+ CD14+/- "patrolling" monocytes. Mature CD16b, by contrast, is slightly smaller that CD16a, but still shows the same 50-70 kSDa electrophoretic pattern in SDS-PAGE. It is a GPI-linked glycoprotein that is 184 aa in length. On the cell surface, CD16b is monomeric. The standard allele (= NA2) is encoded by the SwissProt Accession # used for this product (see above). The two variant alleles are NA1, which shows four aa substitutions, and SH, which contains only one aa substitution relative to the NA2 sequence. CD16b expression appears to be limited to neutrophils. CD16b is known to be solubilized, and the soluble form is believed to arise from the action of ADAM-17 rather than a phospholipase. Over aa 20-208, human CD16a and CD16b share 97% aa sequence identity. Over the same aa range, human CD16b and mouse CD16 share only 47% aa sequence identity.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Immunoprecipitation.

Showing Publication 1 - 1 of 1.

Publication using FAB2546B	Applications	Species
G Saggu, K Okubo, Y Chen, R Vattepu, N Tsuboi, F Rosetti, X Cullere, N Washburn, S Tahir, AM Rosado, SM Holland, RM Anthony, M Sen, C Zhu, TN Mayadas Cis interaction between sialylated Fc?RIIA and the ?I-domain of Mac-1 limits antibody-mediated neutrophil recruitment Nat Commun, 2018-11-29;9(1):5058. 2018-11-29 [PMID: 30498196] (Immunoprecipitation, Human)	Immunoprecipitation	Human

Array FAB2546B

• Fc gamma RIII (CD16) Antibodies
• Fc gamma RIII (CD16) Antibody Pair
• Fc gamma RIII (CD16) Proteins and Enzymes