FBXW7/Cdc4 Antibody (800201)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

F‑box/WD repeat-containing protein 7 (FBXW7), also known as SEL10, CDC4, and AGO, is an approxiimately 110 kDa protein that functions as a substrate recognition component in SCF E3 ubiquitin-protein ligase complexes. FBXW7-containing complexes also contain CUL1, RBX1, and SKP1 and are responsible for the targeting of multiple proteins involved in cell cycle activation. It plays an important role during embryonic development, in the maintenance of neural, oligodendrocyte, and hematopoietic progenitor cells, and in hepatocyte and adipocyte differentiation. FBXW7 is downregulated or mutated in a variety of cancers.  FBXW7 contains one F‑box domain (aa 278-324) and seven tandem WD repeats (aa 378-659). Alternative splicing generates additional isoforms of human FBXW7 that have deletions and/or substitutions of the N-terminal 167 amino acids. Within aa 377-707, human FBXW7 shares 99.7% and 88% aa sequence identity with mouse and rat FBXW7, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: ICC, Western Blot.

Showing Publications 1 - 3 of 3.

Publications using MAB7776	Applications	Species
H Xia, C Scholtes, CR Dufour, C Ouellet, M Ghahremani, V Giguère Insulin action and resistance are dependent on a GSK3beta-FBXW7-ERRalpha transcriptional axis Nature Communications, 2022-04-19;13(1):2105. 2022-04-19 [PMID: 35440636] (Western Blot, Mouse)	Western Blot	Mouse
JY Wang, B Zhu, LL Patterson, MR Rogan, CE Kibler, JW McBride Ehrlichia chaffeensis�TRP120-mediated ubiquitination and proteasomal degradation of tumor suppressor FBW7 increases oncoprotein stability and promotes infection PLoS Pathog., 2020-04-30;16(4):e1008541. 2020-04-30 [PMID: 32353058] (ICC, Western Blot, Human)	ICC, Western Blot	Human
Park J, Kang H, Lee Y, Kang H, Kim J, Chung J, Chang J, McPherron A, Lee S Inactivation of EWS reduces PGC-1alpha protein stability and mitochondrial homeostasis. Proc Natl Acad Sci U S A, 2015-04-27;112(19):6074-9. 2015-04-27 [PMID: 25918410] (Western Blot, Mouse)	Western Blot	Mouse

Array MAB7776

• FBXW7/Cdc4 Antibodies
• FBXW7/Cdc4 Lysates
• FBXW7/Cdc4 Proteins