FBXW7/Cdc4 Antibody (3D1)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Three transcript variants encoding three different isoforms have been found for this gene.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: ICC/IF, IF/IHC, WB.

Showing Publications 1 - 10 of 14. Show All 14 Publications. Collapse Publications.

Publications using H00055294-M02	Applications	Species
Chan DKH, Collins SD, Buczacki SJA Generation and immunofluorescent validation of gene knockouts in adult human colonic organoids using multi-guide RNA CRISPR-Cas9 STAR protocols 2023-01-03 [PMID: 36598849] (WB, Human)	WB	Human
Su Y, Tairan G, Fen Z et al. Fbw7 Inhibits the Progression of Activated B-Cell Like Diffuse Large B-Cell Lymphoma by Targeting the Positive Feedback Loop of the LDHA/lactate/miR-223 Axis. Front Oncol. 2022-03-10 [PMID: 35359405]
Hatem E, Kensuke Y, Toshihiko Y et al. MicroRNA-25 Exerts an Oncogenic Function by Regulating the Ubiquitin Ligase Fbxw7 in Hepatocellular Carcinoma. Ann Surg Oncol. 2021-04-22 [PMID: 33886022]
Koga Y, Iwatsuki M, Yamashita K et al. The role of FBXW7, a cell-cycle regulator, as a predictive marker of recurrence of gastrointestinal stromal tumors. Gastric Cancer. 2019-03-11 [PMID: 30854619]
Yao S, Xu F, Chen Y et al. Fbw7 regulates apoptosis in activated B-cell like diffuse large B-cell lymphoma by targeting Stat3 for ubiquitylation and degradation. J Exp Clin Cancer Res 2017-01-10 [PMID: 28069035]
Hua J, Ding T, Yang L. Dysfunction of microRNA-32 regulates ubiquitin ligase FBXW7 in multiple myeloma disease. Onco Targets Ther 2016-10-25 [PMID: 27822062]
Yumimoto K, Akiyoshi S, Ueo H et al. F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner. J Clin Invest. 2015-01-02 [PMID: 25555218]
Yokobori T, Yokoyama Y, Mogi A et al. FBXW7 Mediates Chemotherapeutic Sensitivity and Prognosis in NSCLC. Mol Cancer Res. 2013-10-28 [PMID: 24165483]
Enchev RI, Scott DC, da Fonseca PC et al. Structural Basis for a Reciprocal Regulation between SCF and CSN. Cell Rep. 2012-09-05 [PMID: 22959436]
Chan D, Mandal A, Collins S et al. Mutational order and epistasis determine the consequences ofFBXW7mutations during colorectal cancer evolution bioRxiv 2023-08-28 (ICC/IF, Human)	ICC/IF	Human
Dickson EL, Vogel R, Leung S et al. FBxW7 as a predictor of outcomes in ovarian cancer. Journal of the American College of Surgeons 2013-01-01 [PMID: 25526310]
Dickson EL, Vogel R, Leung S et al. FBxW7 as a predictor of outcomes in ovarian cancer. J Am Coll Surg 2014-09-01 (IF/IHC, Human)	IF/IHC	Human
Arita H, Nagata M, Yoshida R et al. FBXW7 expression affects the response to chemoradiotherapy and overall survival among patients with oral squamous cell carcinoma: A single-center retrospective study. Tumour Biol 2017-10-26 [PMID: 29072128]
Lin DC, Hao JJ, Nagata Y et al. Genomic and molecular characterization of esophageal squamous cell carcinoma. Nat Genet 2014-05-01 [PMID: 24686850]
Show All 14 Publications. Collapse Publications.

Array H00055294-M02

• FBXW7/Cdc4 Antibodies
• FBXW7/Cdc4 Lysates
• FBXW7/Cdc4 Proteins