EIF3A Antibody

Eukaryotic initiation factor 3 subunit A (eIF3A) is one of at least 13 non-identical protein subunits of eukaryotic initiation factor 3 (eIF3). eIF3 is the largest eIF (~650 kDa) and functions to facilitate binding of the 40S ribosomal subunit to the 5-end of cellular mRNAs near the cap structure (m7GpppN). eIF3A is also known as EIF3S10 (eukaryotic initiation factor 3 subunit 7). eIF3A is the largest subunit of the eIF3 complex. eIF3A expression is regulated through the cell cycle. It's expression peaks in S-phase and it is proposed to play a role in regulating the translation of mRNAs involved in the regulation of cell cycle progression and proliferation. Alternative names for eIF3A include eIF-3-theta, eIF-3 p167, eIF-3 p170, eIF-3 p180, eIF3-p185, EIF3S10, and KIAA0139.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using NBP1-18891	Applications	Species
Kejiou NS, Ilan L, Aigner S et al. Pyruvate Kinase M (PKM) binds ribosomes in a poly-ADP ribosylation dependent manner to induce translational stalling Nucleic acids research 2023-05-24 [PMID: 37224531] (WB, Human)	WB	Human
Duan H, Zhang S, Zarai Y et al. eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content The EMBO Journal 2023-06-15 [PMID: 37155573]
Zhao Y, Zhao H, Zhang D et al. YTHDF3 Facilitates eIF2AK2 and eIF3A Recruitment on mRNAs to Regulate Translational Processes in Oxaliplatin-Resistant Colorectal Cancer ACS chemical biology 2022-06-15 [PMID: 35708211]
Gong C, Krupka JA, Gao J Et al. Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis Molecular cell 2021-08-18 [PMID: 34437837] (WB, Human)	WB	Human
Hassan Hayek, Lauriane Gross, Aurélie Janvier, Laure Schaeffer, Franck Martin, Gilbert Eriani, Christine Allmang eIF3 interacts with histone H4 messenger RNA to regulate its translation The Journal of Biological Chemistry 2021-03-23 [PMID: 33766559]
Jeong SJ, Park S, Nguyen LT et al. A threonyl-tRNA synthetase-mediated translation initiation machinery Nat Commun 2019-03-22 [PMID: 30902983] (WB, Human)	WB	Human
Toompuu M, Karblane K, Pata P et al. ABCE1 is essential for S phase progression in human cells. Cell Cycle. 2016-03-17 [PMID: 26985706] (WB, Human)	WB	Human
Lee AS, Kranzusch PJ, Cate JH. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression Nature 2015-04-06 [PMID: 25849773] (WB, Human)	WB	Human
Chazal PE, Daguenet E, Wendling C et al. EJC core component MLN51 interacts with eIF3 and activates translation Proc Natl Acad Sci U S A 2013-03-25 [PMID: 23530232] (WB, Human)	WB	Human
Lin Y, Li F, Huang L et al. eIF3 promotes early translation elongation to ensure mitochondrial homeostasis and skeletal muscle health bioRxiv 1905-07-11 (WB, Human)	WB	Human
Lin Y, Li F, Huang L et al. eIF3 Associates with 80S Ribosomes to Promote Translation Elongation, Mitochondrial Homeostasis, and Muscle Health Mol. Cell 2020-08-20 [PMID: 32589965] (WB)	WB
Show All 11 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	WB	Other	06/17/2016	View Summary Application Western Blot Sample Tested Xenopus brain lysate Species Other

Array NBP1-18891

• EIF3A Antibodies
• EIF3A Lysate
• EIF3A Proteins