Dnmt2 Antibody

Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. Dnmt2 contains all the sequence motifs diagnostic of DNA (cytosine-5)-methyltransferases but appears to lack the large N-terminal regulatory domain common to other eukaryotic methyltransferases.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publication 1 - 1 of 1.

Publication using NB200-616	Applications	Species
Wu Y, Alvarez M, Slamon DJ et al. Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation. BMC Cancer. 2010-02-04 [PMID: 20132554] (WB, Human) Details: Dnmt1 (IMG-261A),Dnmt2 (IMG-281), Dnmt3a (IMG-268A), Dnmt3b (IMG-184A). WB: Human breast cancer MCF-7, MB231, BT474 cell lines treated with or without 5-aza-dc, Fig 4.	WB	Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	WB	Mouse	07/17/2014	View Summary Application Western Blot Sample Tested Lysate from homogenized mouse brain cells Species Mouse

Array NB200-616

• Dnmt2 Antibodies
• Dnmt2 Lysate
• Dnmt2 Proteins