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DNA Polymerase gamma Antibody (9V9D9)

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Western Blot: DNA Polymerase gamma Antibody (9V9D9) [NBP3-15460] - Western blot analysis of extracts of various cell lines, using DNA Polymerase gamma Rabbit mAb (NBP3-15460) at 1:1000 dilution. Secondary antibody: HRP ...read more
Western Blot: DNA Polymerase gamma Antibody (9V9D9) [NBP3-15460] - Western blot analysis of extracts of various cell lines, using DNA Polymerase gamma Rabbit mAb (NBP3-15460) at 1:1000 dilution. Secondary antibody: HRP ...read more

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB
Clone
9V9D9
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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DNA Polymerase gamma Antibody (9V9D9) Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1140-1239 of human DNA Polymerase gamma (P54098). LVREEDRYRAALALQITNLLTRCMFAYKLGLNDLPQSVAFFSAVDIDRCLRKEVTMDCKTPSNPTGMERRYGIPQGEALDIYQIIELTKGSLEKRSQPGP
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
POLG
Purity
Affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500 - 1:1000

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS, 0.05% BSA, 50% glycerol, pH7.3
Preservative
0.02% Sodium Azide
Purity
Affinity purified

Alternate Names for DNA Polymerase gamma Antibody (9V9D9)

  • DNA Polymerase gamma
  • DNA polymerase subunit gamma-1
  • EC 2.7.7.7
  • FLJ27114
  • MDP1
  • MIRAS
  • Mitochondrial DNA polymerase catalytic subunit
  • MTDPS4A
  • POLG
  • PolG, catalytic subunit
  • POLG1
  • POLG1MTDPS4B
  • POLGA
  • PolG-alpha
  • POLGAPEO
  • polymerase (DNA directed), gamma
  • SANDO
  • SCAE

Background

As the only DNA polymerase (pol) present in mitochondria, DNA polymerase gamma (POLG) is necessarily implicated in base excision repair processes to correct oxidative damage to the mitochondrial genome. Therefore, the ability of the catalytic subunit of human POLG has been tested to participate in uracil-provoked base excision repair reconstituted in vitro with purified components. Subsequent to actions of uracil-DNA glycosylase and apurinic/apyrimidinic endonuclease, human POLG is able to fill a single nucleotide gap in the presence of a 5' terminal deoxyribose phosphate (dRP) flap. The catalytic subunit of human pol gamma catalyzes release of the dRP residue from incised apurinic/apyrimidinic sites to produce a substrate for DNA ligase. Faulty replication of the human mitochondrial genome is thought to be the cause of many diseases. The low selectivity of the mitochondrial DNA polymerase is implicated as the cause of many side effects observed in the treatment of viral infections such as HIV.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol POLG