DNA Polymerase gamma Products

Description

As the only DNA polymerase (pol) present in mitochondria, DNA polymerase gamma (POLG) is necessarily implicated in base excision repair processes to correct oxidative damage to the mitochondrial genome. Therefore, the ability of the catalytic subunit of human POLG has been tested to participate in uracil-provoked base excision repair reconstituted in vitro with purified components. Subsequent to actions of uracil-DNA glycosylase and apurinic/apyrimidinic endonuclease, human POLG is able to fill a single nucleotide gap in the presence of a 5' terminal deoxyribose phosphate (dRP) flap. The catalytic subunit of human pol gamma catalyzes release of the dRP residue from incised apurinic/apyrimidinic sites to produce a substrate for DNA ligase. Faulty replication of the human mitochondrial genome is thought to be the cause of many diseases. The low selectivity of the mitochondrial DNA polymerase is implicated as the cause of many side effects observed in the treatment of viral infections such as HIV.

Bioinformatics

Entrez	5428 Human 85472 Rat
Uniprot	AAH50559 Human P54098 Human
Product By Gene ID	5428
Alternate Names	DNA polymerase subunit gamma-1 EC 2.7.7.7 FLJ27114 MDP1 MIRAS Mitochondrial DNA polymerase catalytic subunit MTDPS4A PolG, catalytic subunit POLG1MTDPS4B PolG-alpha POLGAPEO polymerase (DNA directed), gamma SANDO SCAE

Research Areas for DNA Polymerase gamma

Find related products by research area and learn more about each of the different research areas below.

DNA Polymerases
DNA Repair