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DHCR7 Antibody

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Western Blot: DHCR7 Antibody [NBP2-84783] - Host: Rabbit. Target Name: DHCR7. Sample Tissue: Human NCI-H226 Whole Cell lysates. Antibody Dilution: 1ug/ml
Western Blot: DHCR7 Antibody [NBP2-84783] - Host: Rabbit. Target Name: DHCR7. Sample Tissue: Human NCI-H226 Whole Cell lysates. Antibody Dilution: 1ug/ml

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.5 mg/ml

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DHCR7 Antibody Summary

Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human DHCR7. Peptide sequence: AAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAP The peptide sequence for this immunogen was taken from within the described region.
Clonality
Polyclonal
Host
Rabbit
Gene
DHCR7
Purity
Affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1.0 ug/ml

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS, 2% Sucrose
Preservative
0.09% Sodium Azide
Concentration
0.5 mg/ml
Purity
Affinity purified

Alternate Names for DHCR7 Antibody

  • 7-dehydrocholesterol reductase
  • 7-DHC reductase
  • D7SR
  • delta-7-dehydrocholesterol reductase
  • EC 1.3.1
  • EC 1.3.1.21
  • Putative sterol reductase SR-2
  • SLOS
  • Smith-Lemli-Opitz syndrome
  • Sterol Delta(7)-reductase
  • sterol delta-7-reductase

Background

The DHCR7 gene encodes delta-7-sterol reductase (EC 1.3.1.21), the penultimate enzyme of mammalian sterol biosynthesis that converts 7-dehydrocholesterol (7-DHC) to cholesterol. This enzyme removes the C(7-8) double bond introduced by the sterol delta8-delta7 isomerases. In addition, its role in drug-induced malformations is known: inhibitors of the last step of cholesterol biosynthesis such as AY9944 and BM15766 severely impair brain development (Moebius et al., 1998 [PubMed 9465114]).[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol DHCR7