DDR1 Antibody

discoidin domain receptor tyrosine kinase 1. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: IHC-P, WB.

Showing Publications 1 - 2 of 2.

Publications using NBP1-33134	Applications	Species
Torun YM, Delen E, Doganlar O et al. Effects of Expression of Matrix Metalloproteinases and Discoidin Domain Receptors in Ligamentum Flavum Fibrosis in Patients with Degenerative Lumbar Canal Stenosis Asian spine journal 2022-09-27 [PMID: 36163678] (WB, Human)	WB	Human
Tao Y, Wang R, Lai Q Targeting of DDR1 with antibody-drug conjugates has antitumor effects in a mouse model of colon carcinoma Mol Oncol 2019-05-22 [PMID: 31116512] (IHC-P, Human, Mouse)	IHC-P	Human, Mouse

Array NBP1-33134

• DDR1 Antibodies
• DDR1 Lysates
• DDR1 ELISAs
• DDR1 Proteins and Enzymes