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Cytosolic beta-Glucosidase/GBA3 Antibody (008) [Janelia Fluor® 635]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, ICC/IF
Clone
008
Clonality
Monoclonal
Host
Rabbit
Conjugate
Janelia Fluor 635

Order Details

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Cytosolic beta-Glucosidase/GBA3 Antibody (008) [Janelia Fluor® 635] Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
This antibody was obtained from a rabbit immunized with purified, recombinant Human Cytosolic beta-Glucosidase/GBA3 (Accession#: NP_066024.1; Met1-Leu469).
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
GBA3
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Cytosolic beta-Glucosidase/GBA3 Antibody (008) [Janelia Fluor® 635]

  • CBG
  • CBGL1
  • CBGL1GLUC
  • Cytosolic betaGlucosidase
  • Cytosolic beta-Glucosidase
  • Cytosolic beta-glucosidase-like protein 1
  • EC 3.2.1.21
  • GBA3
  • GLUC
  • glucosidase, beta, acid 3 (cytosolic)
  • klotho-related protein
  • KLrP
  • MGC104276
  • MGC126878

Background

GBA3, or cytosolic beta-glucosidase (EC 3.2.1.21), is a predominantly liver enzyme that efficiently hydrolyzes beta-D-glucoside and beta-D-galactoside, but not any known physiologic beta-glycoside, suggesting that it may be involved in detoxification of plant glycosides (de Graaf et al., 2001 [PubMed 11389701]). GBA3 also has significant neutral glycosylceramidase activity (EC 3.2.1.62), suggesting that it may be involved in a nonlysosomal catabolic pathway of glucosylceramide metabolism (Hayashi et al., 2007 [PubMed 17595169]).[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

ICC/IF Video Protocol

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Bioinformatics

Gene Symbol GBA3