Cytochrome P450 3A4 Antibody (946002) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CYP3A4 (cytochrome P450, subfamily 3A, polypeptide 4) belongs to the cytochrome P450 superfamily of monooxygenases that catalyze reactions involved in both drug metabolism and the synthesis of cholesterol, steroids, and other lipid components.  CYP3A4 is predominantly found in liver microsomes, but has also been detected in prostate, small and large intestine, bile duct, nasal mucosa, kidney and adrenal cortex.  It is an extremely important enzyme for drug metabolism; CYP3A4 catalyzes phase I oxidation reactions in an estimated 60% of all clinically used drugs, promoting in most cases their clearance by excretion.  CYP3A4 levels are induced by glucocorticoids and various xenobiotics, including drugs, pesticides and carcinogens.  Human CYP3A4 is a 50 kDa single-pass membrane protein, 503 amino acids in length.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Simple Western.

Showing Publication 1 - 1 of 1.

Publication using MAB9079	Applications	Species
JM Collins, D Wang Cytochrome P450 3A4 (CYP3A4) protein quantification using capillary western blot technology and total protein normalization Journal of pharmacological and toxicological methods, 2021-08-30;112(0):107117. 2021-08-30 [PMID: 34474151] (Simple Western, Human)	Simple Western	Human

Array MAB9079

• Cytochrome P450 3A4 Antibodies
• Cytochrome P450 3A4 ELISA Kits
• Cytochrome P450 3A4 Protein