CXCL8/IL-8 ELISA Development Kit Summary
Standard Curve Range |
8 - 800 pg/mL |
Sample Volume |
100 uL |
Kit Type |
ELISA Development Kit |
Gene |
CXCL8 |
Applications/Dilutions
Reactivity Notes
Packaging, Storage & Formulations
Storage |
Storage of components varies. See protocol for specific instructions. |
Kit Components
Components
|
- Biotinylated detection mAb (26E5)
- Capture mAb (MT8H6)
- Recombinant bovine IL-8 ELISA standard (lyophilized)
- Standard reconstitution buffer
- Streptavidin-HRP
|
Alternate Names for CXCL8/IL-8 ELISA Development Kit
Background
IL8 is a member of the CXC chemokine family. This family of small basic heparan-binding proteins are proinflammatory and primarily mediate the activation and migration of neutrophils into tissue from peripheral blood. This chemokine is one of the major mediators of the inflammatory response and is secreted by several cell types in response to an inflammatory stimulus. It functions as a chemoattractant, and is also a potent angiogenic factor. IL8 attracts neutrophils, basophils, and T-cells, but not monocytes. Cystic fibrosis (CF) is characterized by severe lung inflammation. The inflammatory process is believed to be caused by massive overproduction of the proinflammatory protein IL8, and the high levels of IL8 in the CF lung are therefore believed to be the central mechanism behind CF lung pathophysiology.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Kits are
guaranteed for 6 months from date of receipt.
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