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CSE1L/CAS/Exportin-2 Antibody

Images

 
Immunocytochemistry/ Immunofluorescence: CSE1L/CAS/Exportin-2 Antibody [NBP2-38384] - Staining of human cell line CACO-2 shows positivity in cytoplasm and nucleus but excluded from the nucleoli.
Immunohistochemistry-Paraffin: CSE1L/CAS/Exportin-2 Antibody [NBP2-38384] - Staining of human liver.
Immunohistochemistry-Paraffin: CSE1L/CAS/Exportin-2 Antibody [NBP2-38384] - Staining of human pancreas shows low expression as expected.
Immunohistochemistry-Paraffin: CSE1L/CAS/Exportin-2 Antibody [NBP2-38384] - Staining of human testis shows high expression.
Orthogonal Strategies: Immunohistochemistry-Paraffin: CSE1L/CAS/Exportin-2 Antibody [NBP2-38384] - Staining in human testis and pancreas tissues using anti-CSE1L antibody. Corresponding CSE1L RNA-seq data are ...read more
Independent Antibodies: Immunohistochemistry-Paraffin: CSE1L/CAS/Exportin-2 Antibody [NBP2-38384] - Staining of human cerebral cortex, colon, liver and testis using Anti-CSE1L antibody NBP2-38384 (A) shows ...read more
Immunohistochemistry-Paraffin: CSE1L/CAS/Exportin-2 Antibody [NBP2-38384] - Staining of human cerebral cortex.
Immunohistochemistry-Paraffin: CSE1L/CAS/Exportin-2 Antibody [NBP2-38384] - Staining of human colon.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

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CSE1L/CAS/Exportin-2 Antibody Summary

Immunogen
This antibody was developed against a recombinant protein corresponding to amino acids: HGITQANELVNLTEFFVNHILPDLKSANVNEFPVLKADGIKYIMIFRNQVPKEHLLVSIPLLINHLQAESIVVHTYAAHALERLFTMRGPNNATLF
Predicted Species
Mouse (95%), Rat (97%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CSE1L
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence 0.25-2 ug/ml
  • Immunohistochemistry 1:20 - 1:50
  • Immunohistochemistry-Paraffin 1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.
Control Peptide
CSE1L/CAS/Exportin-2 Protein (NBP2-38384PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for CSE1L/CAS/Exportin-2 Antibody

  • CAS
  • CASMGC117283
  • Cellular apoptosis susceptibility protein
  • chromosome segregation 1 (yeast homolog)-like
  • Chromosome segregation 1-like protein
  • CSE1 chromosome segregation 1-like (yeast)
  • CSE1
  • CSE1L
  • exp2
  • exportin-2
  • Importin-alpha re-exporter
  • MGC130037
  • XPO2
  • XPO2MGC130036

Background

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol CSE1L
Uniprot