CMG-2/ANTXR2 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Capillary Morphogenesis Gene-2 (CMG-2) is a widely expressed anthrax toxin receptor (ATR) family protein (1‑3). CMG-2 is a 55 kDa type I transmembrane (TM) protein that contains a 33 amino acid (aa) signal sequence, a 284 aa extracellular domain (ECD), a 24 aa TM segment, and a 147 aa cytoplasmic domain. There are three additional isoforms. Isoforms 4 shows a 12 aa insertion in the cytoplasmic region; isoform 2 shows a 103 aa deletion in the ECD; and isoform 3 is a truncated, 20 kDa, 289 aa soluble form. The main functional domain of CMG-2 is an extracellular integrin-like von Willebrand factor type A (VWA) domain with a metal ion dependent adhesion site (MIDAS). This domain adheres selectively to collagen type IV and laminin (1‑5). CMG-2 isoform 2 is induced in HUVEC as they undergo capillary formation in collagen matrices in vitro (3). CMG-2 is mutated in juvenile hyaline fibromatosis and infantile systemic hyalinosis disorders, and several of these mutations result in loss of laminin binding (6). CMG-2 and the related protein ATR/TEM8 serve as receptors for the protective antigen (PA) of Bacillus Anthracis (1, 2). After binding the VWA domain, PA undergoes furin-type cleavage, forms a heptameric receptor/PA pre-pore and binds LF or EF toxin subunits (5, 7, 8). Transport to low pH endosomes, which requires CMG-2 ubiquitination and interaction with the LDL receptor related protein LRP6 (9, 10), allows PA pore formation and release of toxin to the cytoplasm (10, 11). Soluble CMG-2 VWA domain acts as a dummy receptor that can protect cultured cells from anthrax intoxication (2). Within the extracellular region, human CMG-2 shares 84%, 81%,89% and 93% amino acid sequence homology with mouse, rat, bovine, and canine CMG-2, respectively. CMG-2 VWA domain also shares 60% aa identity with ATR/TEM8.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: Flow Cytometry, Immunoprecipitation, STED Microscopy, Western Blot.

Showing Publications 1 - 8 of 8.

Publications using AF2940	Applications	Species
E Castroflor, AJ Pérez Bern, A López-Márq, C Badosa, P Loza-Alvar, M Roldán, C Jiménez-Ma The Capillary Morphogenesis Gene 2 Triggers the Intracellular Hallmarks of Collagen VI-Related Muscular Dystrophy International Journal of Molecular Sciences, 2022-07-11;23(14):. 2022-07-11 [PMID: 35886995] (STED Microscopy, Western Blot, Human)	STED Microscopy, Western Blot	Human
Elsa Perrody, Laurence Abrami, Michal Feldman, Beatrice Kunz, Sylvie Urbé, F Gisou van der Goot Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6 eLife 10/18/2016 [PMID: 27751231]
Friebe S, Deuquet J, van der Goot F Differential dependence on N-glycosylation of anthrax toxin receptors CMG2 and TEM8. PLoS ONE, 2015-03-17;10(3):e0119864. 2015-03-17 [PMID: 25781883] (Immunoprecipitation, Human)	Immunoprecipitation	Human
Ye L, Sun P, Sanders A, Martin T, Lane J, Mason M, Jiang W Therapeutic potential of capillary morphogenesis gene 2 extracellular vWA domain in tumourrelated angiogenesis. Int J Oncol, 2014-07-03;45(4):1565-73. 2014-07-03 [PMID: 24993339] (Western Blot, Human)	Western Blot	Human
Ye , Lin, Sanders , Andrew J, Sun , Ping-Hui, Mason , Malcolm, Jiang , Wen G Capillary morphogenesis gene 2 regulates adhesion and invasiveness of prostate cancer cells. Oncol Lett, 2014-04-04;7(6):2149-2153. 2014-04-04 [PMID: 24932305] (Western Blot, Human)	Western Blot	Human
Langer , Marybeth, Duggan , Elizabet, Booth , John Lel, Patel , Vineet I, Zander , Ryan A, Silasi-Mansat , Robert, Ramani , Vijay, Veres , Tibor Zo, Prenzler , Frauke, Sewald , Katherin, Williams , Daniel M, Coggeshall , Kenneth, Awasthi , Shanjana, Lupu , Florea, Burian , Dennis, Ballard , Jimmy Da, Braun , Armin, Metcalf , Jordan P Bacillus anthracis lethal toxin reduces human alveolar epithelial barrier function. Infect Immun, 2012-10-01;80(12):4374-87. 2012-10-01 [PMID: 23027535] (Flow Cytometry, Western Blot, Human)	Flow Cytometry, Western Blot	Human
Julie Deuquet, Ekkehart Lausch, Nicolas Guex, Laurence Abrami, Suzanne Salvi, Asvin Lakkaraju et al. Hyaline Fibromatosis Syndrome inducing mutations in the ectodomain of anthrax toxin receptor 2 can be rescued by proteasome inhibitors EMBO Molecular Medicine 4/1/2011 [PMID: 21328543]
Wu W, Mehta H, Chakrabarty K, Booth JL, Duggan ES, Patel KB, Ballard JD, Coggeshall KM, Metcalf JP Resistance of human alveolar macrophages to Bacillus anthracis lethal toxin. J. Immunol., 2009-10-07;183(9):5799-806. 2009-10-07 [PMID: 19812208] (Western Blot, Human)	Western Blot	Human

Array AF2940

• CMG-2/ANTXR2 Antibodies
• CMG-2/ANTXR2 ELISA Kit
• CMG-2/ANTXR2 Lysate
• CMG-2/ANTXR2 Proteins and Enzymes
• CMG-2/ANTXR2 ELISA