Claudin-11 Antibody

Oligodendrocyte specific protein belongs is a major component of central nervous system myelin that is necessary for normal CNS function. The claudin superfamily consists of many structurally related proteins in humans. These proteins, which include claudin 1 through 18, and are located in both epithelial and endothelial cells in all tight junction bearing tissues. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. There is growing evidence that the Claudin 11 protein determines the permeability between layers of myelin sheaths via focal adhesion and with its expression highly regulated during development, may play an important role in cellular proliferation and migration. In addition, the protein is a candidate autoantigen in the development of autoimmune demyelinating disease.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: IHC-P, Immunocytochemistry/ Immunofluorescence, WB.

Showing Publications 1 - 5 of 5.

Publications using NBP1-82470	Applications	Species
Mapunda JA, Pareja J, Vladymyrov M et al. VE-cadherin in arachnoid and pia mater cells serves as a suitable landmark for in vivo imaging of CNS immune surveillance and inflammation Nat Commun 2023-09-20 [PMID: 37730744] (Immunocytochemistry/ Immunofluorescence)	Immunocytochemistry/ Immunofluorescence
MOROKI T, MATSUO S, HATAKEYAMA H et al. Databases for technical aspects of immunohistochemistry-2021 update Journal of Toxicologic Pathology 2021-02-24 [PMID: 33976473]
Furukawa S, Nagaike M, Ozaki K. Databases for technical aspects of immunohistochemistry. J Toxicol Pathol 2017-01-01 [PMID: 28190929]
Marthandan S, Priebe S, Baumgart M et al. Similarities in Gene Expression Profiles during In Vitro Aging of Primary Human Embryonic Lung and Foreskin Fibroblasts. Biomed Res Int 2015-01-01 [PMID: 26339636] (WB, Human)	WB	Human
Anagawa-Nakamura A, Kakimoto K, Miyajima K et al. Immunohistochemical Characterization of Spontaneous Sertoli Cell Clusters in the Seminiferous Tubules of C57BL/6J Mice Toxicol Pathol. 2015-01-27 [PMID: 25630681] (IHC-P, Mouse) Details: Claudin-11 antibody used for IHC-P on transverse section of testes and longitudinal section from epididymis from six-week-old male C57BL/6J mice subjected to 2-week oral dose toxicity study treatment schedule. The immunostaining assay involved - antigen retrieval via boiling the sections for 15 min in 10mM sodium citrate buffer pH 6, primary antibody dilution of 1:100, signal detection with Histofine Simple Stain MAX-PO. In testes, Claudin-11 is expected to express at Sertoli cell tight junctions, wherein, it is considered as a marker for Sertoli cells and in the current study, clusters of cells in the testes as well as some cell aggregates/cell debris in the lumen of the epididymis representing sloughed off Sertoli cells were found positive for Claudin-11 (Figure 2).	IHC-P	Mouse

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Jerome Breslin	Simple Western	Human	06/07/2021	View Summary Application Simple Western Sample Tested HUVEC (Human Umbilical Vein Endothelial Cells) Species Human Lot A105899 Comments Comments All test lanes utilized 0.2 mg/ml protein concentrations. The WES anti-rabbit antibody kit was used.

Array NBP1-82470

• Claudin-11 Antibodies
• Claudin-11 ELISA Kits
• Claudin-11 Lysate
• Claudin-11 Protein