Cited-2 Antibody (JA22) - BSA Free

CITED2 (Cbp/p300-interacting transactivator 2; also called MSG-related protein 1/ MRG1 or P35srj) is a CREBBP/EP300-interacting protein which is highly conserved in placental mammals with 95% identity shared between human and mouse protein. CITED2 is a transcriptional co-activator that stabilizes the interactions between DNA-binding proteins and the histone acetyltransferases CBP (CREB -binding protein) as well as p300. It is localized in the nucleus and can be induced upon hypoxic trigger wherein it functions as a negative regulator of HIF1 mediated signaling by competing with HIF1alpha for binding to CBP/p300. Additionally, CITED2 gets induced by several biological stimuli such as cytokines, serum and LPS in different cell type. CITED2 interacts with a diverse array of proteins including SMAD2, SMAD3, LHX1/2, ESR1/2, WT1, EP300, PPARA, TFAP2A, TFAP2B, TFAP2C, HNF4A etc and exerts versatile biological activities. CITED2 is a critical transcriptional cofactor involved in multiple organ development and mice lacking CITED2 die in utero with cardiac and aortic arch malformations, adrenal gland agenesis, small cranial and dorsal root ganglia, exencephaly, and neural crest and left-right patterning defects. Defects in CITED2 have been linked to ventricular septal defect type 2 (VSD2) and atrial septal defect type 8 (ASD8).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: IHC-P, WB.

Showing Publications 1 - 10 of 14. Show All 14 Publications. Collapse Publications.

Publications using NB100-136	Applications	Species
Lau WM, Doucet M, Huang D et al. CITED2 modulates estrogen receptor transcriptional activity in breast cancer cells. Biochem Biophys Res Commun 2013-06-27 [PMID: 23811274] (WB, Human)	WB	Human
Biao Zeng, Jianguo Hu, Rui Yuan, LiNa Hu, Ling Zhong, Kai Kang Increased expression of importin13 in endometriosis and endometrial carcinoma Medical Science Monitor : International Medical Journal of Experimental and Clinical Research 2012-01-01 [PMID: 22648251]
JianGuo Hu, Rui Yuan The expression levels of stem cell markers importin13, c-kit, CD146, and telomerase are decreased in endometrial polyps Medical Science Monitor : International Medical Journal of Experimental and Clinical Research 2011-01-01 [PMID: 21804459]
Goncalves AM, de Sanctis D, McSweeney SM. Structural and functional insights into DR2231 protein, the MazG-like nucleoside triphosphate pyrophosphohydrolase from Deinococcus radiodurans. J Biol Chem 2011-09-02 [PMID: 21733847]
Sengupta A, Molkentin JD, Paik JH. FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress. J Biol Chem. 2010-12-15 [PMID: 21159781]
Yang Y, Dahly-Vernon AJ, Blomme EA et al. Liver transcriptomic changes associated with ritonavir-induced hyperlipidemia in sensitive and resistant strains of rats. Vet J 2010-07-01 [PMID: 20547082]
Lau WM, Weber KL, Doucet M et al. Identification of prospective factors promoting osteotropism in breast cancer: a potential role for CITED2. Int J Cancer 2010-02-15 [PMID: 19642106] (WB, Mouse)	WB	Mouse
Haase M, Ansurudeen I, Schinner S. et al et al. Evidence for the involvement of endothelial cell products in adrenal CITED2 expression. Cell Tissue Res 2009-05-01 [PMID: 19319572] (WB, IHC-P, Human)	WB, IHC-P	Human
Gonzalez YR, Zhang Y, Behzadpoor D, Cregan S, Bamforth S, Slack RS, Park DS. CITED2 signals through peroxisome proliferator-activated receptor-gamma to regulate death of cortical neurons after DNA damage. J Neurosci;28(21):5559-69. 2008-05-21 [PMID: 18495890]
Warnecke C, Weidemann A, Volke M et al. The specific contribution of hypoxia-inducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors. Exp Cell Res 2008-06-10 [PMID: 18420194]
Haase, M et al. CITED2 is expressed in human adrenocortical cells and regulated by basic fibroblast growth factor. J Endocrinol;192(2):459-65. 2007-02-01 [PMID: 17283246]
Bamforth, S et al. Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway. Nat Genet;36(11):1189-96. 2004-11-01 [PMID: 15475956]
Tien, E et al. Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator. J Biol Chem;279(23):24053-63. 2004-06-04 [PMID: 15051727]
Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM. Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev;13(1):64-75. 1999-01-01 [PMID: 9887100]
Show All 14 Publications. Collapse Publications.

Array NB100-136

• Cited-2 Antibodies
• Cited-2 Lysate
• Cited-2 Protein