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ChemR23/CMKLR1 Antibody (BZ194) [Janelia Fluor® 635]

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Summary
Product Discontinued
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    • Catalog Number
      NBP3-11984JF635
    • Availability
      Product Discontinued

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ChemR23/CMKLR1 Antibody (BZ194) [Janelia Fluor® 635] Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
This antibody was raised by immunising Wistar Furth rats with the mChemR23/CMKLR1 peptide/KLH conjugate. The immunizing amino-terminal mChemR23/CMKLR1 peptide with the sequence NH2-DSGIYDDEYSDGFGYFVDLEEASPWC-COOH, corresponding to residues residues 8-32 of mChemR23/CMKLR1, with a nonnative carboxyl-terminal cysteine to facilitate conjugation to keyhole limpet hemocyanin (KLH).
Specificity
This antibody is specific for murine serpentine receptor mChemR23/CMKLR1 (aka ChemR23, DEZ). mChemR23/CMKLR1 is a novel protein possessing high homology with members of the chemoattractant receptor family, and binds the chemoattractant chemerin. Selective mChemR23/CMKLR1 expression has been demonstrated by mouse macrophages ex vivo, and by dendritic cell precursors cultured in vitro.
Isotype
IgG Kappa
Clonality
Monoclonal
Host
Rabbit
Gene
CMKLR1
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunoprecipitation
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for ChemR23/CMKLR1 Antibody (BZ194) [Janelia Fluor® 635]

  • CHEMERINR
  • chemokine receptor-like 1
  • chemokine-like receptor 1
  • ChemR23
  • cmklr1
  • Dez
  • Gpcr27
  • G-protein coupled receptor ChemR23
  • G-protein coupled receptor DEZ
  • MGC126105
  • MGC126106
  • orphan G-protein coupled receptor, Dez

Background

Chemokine-Like Receptor 1 (CMKLR1) is an chemoattractant receptor. CMKLR1 is thought to act primarily in bone development where it is differentially regulated in osseous and cartilaginous tissue. It also acts as a coreceptor for immunodeficiency viruses. CMKLR1 has two variants that are produced by alternative splicing. Chemokine-like receptor 1 (CMKLR1) has been reported to be expressed in bone marrow, liver, appendix, thymus, lymph node, placenta, and spleen. ESTs have been isolated from human normal kidney and testis libraries and from a prostate cancer library.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CMKLR1