Reactivity | Hu, Pm, PmSpecies Glossary |
Applications | Flow, ICC/IF, IHC, CyTOF-ready, ICC/IF |
Clone | CR1/802 |
Clonality | Monoclonal |
Host | Mouse |
Conjugate | PE/Cy7 |
Immunogen | Recombinant full-length human CD35 protein (Uniprot: P17927) |
Localization | Cell surface |
Marker | Follicular Dendritic Cell Marker |
Specificity | Recognizes a protein of 210-220kDa, which is identified as the complement receptor 1 (CR1)/CD35. This monoclonal antibody does not block CR1 activity. It is highly specific to CR1 and shows no cross-reaction with CR2. The primary function of CR1 is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. The Knops blood group system is a system of antigens located on this protein. Follicular dendritic cells (FDC) are restricted to the B-cell regions of secondary lymphoid follicles. They are CD21+/CD35+/CD1a-. This monoclonal antibody labels follicular dendritic cells and follicular dendritic cell sarcoma. |
Isotype | IgG1 Kappa |
Clonality | Monoclonal |
Host | Mouse |
Gene | CR1 |
Purity | Protein A or G purified |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Dilutions |
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Application Notes | Optimal dilution of this antibody should be experimentally determined. For optimal results using our Tandem dyes, please avoid prolonged exposure to light or extreme temperature fluctuations. These can lead to irreversible degradation or decoupling. When staining intracellular targets, specific attention to the fixation and permeabilization steps in your flow protocol may be required. Please contact our technical support team at technical@novusbio.com if you have any questions. |
Storage | Store at 4C in the dark. Do not freeze. |
Buffer | PBS |
Preservative | 0.05% Sodium Azide |
Purity | Protein A or G purified |
Secondary Antibodies |
Isotype Controls |
Research Areas for CD35 Antibody (NBP2-47865PECY7)Find related products by research area.
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Gene Symbol | CR1 |