Canine reactivity reported in scientific literature (PMID: 25375819).
Packaging, Storage & Formulations
Storage
Store at 4C in the dark.
Buffer
NaBorate
Preservative
0.09% Sodium Azide
Purity
Protein A or G purified
Notes
This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
Alternate Names for CD14 Antibody (M5E2) [FITC]
CD14 antigen
CD14 molecule
CD14
monocyte differentiation antigen CD14
Myeloid cell-specific leucine-rich glycoprotein
Background
CD14 is a 53-55 kD glycosylphosphatidylinositol (GPI)-linked membrane glycoprotein also known as LPS receptor. CD14 is expressed at high levels on monocytes and macrophages, and at lower levels on granulocytes. Some dendritic cell populations such as interfollicular dendritic cells, reticular dendritic cells, and Langerhans cells have also been reported to express CD14. As a high-affinity receptor for LPS, CD14 is involved in the clearance of gram-negative pathogens and in the upregulation of adhesion molecules and cytokines expression in monocytes and neutrophils. The M5E2 antibody inhibits monocyte activation and cytokine production induced by LPS.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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