CD14 Antibody (159010) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CD14 is a 55 kDa cell surface glycoprotein that is preferentially expressed on monocytes/macrophages. The mouse CD14 cDNA encodes a 366 amino acid (aa) residue precursor protein with a 15 aa signal peptide and a C-terminal hydrophobic region characteristic for glycosylphosphatidyinositol (GPI)-anchored proteins. Mouse CD14 has five potential N-linked glycosylation sites and also bears O-linked carbohydrates. The amino acid sequence of mouse CD14 is approximately 65% and 82% identical to the human and rat proteins, respectively. CD14 is a pattern recognition receptor that binds lipopolysaccharides (LPS) and a variety of ligands derived from different microbial sources. The binding of CD14 with LPS is catalyzed by LPS-binding protein (LBP). The toll-like-receptors have also been implicated in the transduction of CD14-LPS signals. Similar to other GPI-anchored proteins, soluble CD14 can be released from the cell surface by phosphatidyinositol-specific phospholipase C. Soluble CD14 has been detected in serum and body fluids. High concentrations of soluble CD14 have been shown to inhibit LPS-mediated responses. However, soluble CD14 can also potentiate LPS response in cells that do not express cell surface CD14.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 5 applications: Binding Assay, ICC, IHC-P, In Vivo, Neutralization.

Showing Publications 1 - 4 of 4.

Publications using MAB982	Applications	Species
Ma C, Chang W, Shi G, Chang B, Cheng S, Shih Y, Wu H Recombinant thrombomodulin inhibits lipopolysaccharide-induced inflammatory response by blocking the functions of CD14. J Immunol, 2015-01-21;194(4):1905-15. 2015-01-21 [PMID: 25609841] (Binding Assay, Mouse)	Binding Assay	Mouse
Levy O, Calippe B, Lavalette S, Hu S, Raoul W, Dominguez E, Housset M, Paques M, Sahel J, Bemelmans A, Combadiere C, Guillonneau X, Sennlaub F Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration. EMBO Mol Med, 2015-02-01;7(2):211-26. 2015-02-01 [PMID: 25604058] (In Vivo, Neutralization, Mouse)	In Vivo, Neutralization	Mouse
Hayashida K, Parks WC, Park PW Syndecan-1 shedding facilitates the resolution of neutrophilic inflammation by removing sequestered CXC chemokines. Blood, 2009-07-28;114(14):3033-43. 2009-07-28 [PMID: 19638625] (IHC-P, Mouse)	IHC-P	Mouse
Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton MT, Arulanandam B, Zhang J, Zhong G A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum. J. Immunol., 2009-06-19;183(2):1291-300. 2009-06-19 [PMID: 19542374] (ICC, Mouse)	ICC	Mouse

Array MAB982

• CD14 Antibodies
• CD14 Antibody Pair
• CD14 ELISA Kit
• CD14 Lysates
• CD14 Proteins
• CD14 ELISAs
• CD14 Proteins and Enzymes