Cathepsin E Antibody

Cathepsin E (CTSE) is an intracellular aspartic protease belonging to pepsin superfamily and is highly homologous to the analogous aspartic protease cathepsin D. CTSE is predominantly expressed in cells of immune system including antigen-presenting cells (APC) and has also been detected in gastric epithelial cells as well as osteoclasts. Intracellularly, CTSE is localized in endosomal compartments, plasma membrane, ER and Golgi complex, and is found secreted as activated phagocytes's catalytically active enzyme. CTSE expression and secretion increases in APCs when activated by interferon- gamma and/or LPS. CTSE functions in vivo at physiological pH with a rather restricted specificity and its strategic expression alongwith localization suggests its critical involvement in tissue-specific biological functions which includes antigen processing , neuronal degeneration and generation of various secretory proteins. Human subjects and mice with shortage of CTSE are often prone to atopic dermatitis. Increased CTSE is observed in proliferative diseases such as gastric carcinoma, cervical cancer, and has been considered a promising marker for pancreatic duct cancer.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: WB.

Showing Publication 1 - 1 of 1.

Publication using NB400-152	Applications	Species
Hiramatsu S, Watanabe KS, Zeggar S et al. Regulation of Cathepsin E gene expression by the transcription factor Kaiso in MRL/lpr mice derived CD4+ T cells Sci Rep 2019-02-28 [PMID: 30816218] (WB, Human, Mouse)	WB	Human, Mouse

Array NB400-152

• Cathepsin E Antibodies
• Cathepsin E ELISA Kit
• Cathepsin E Protein
• Cathepsin E Proteins and Enzymes