Caspr1 Antibody

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CASPR1 (Contactin-ASsociated PRotein-1; also Neurexin-4 and p190) is a 180-195 kDa member of the neurexin family of proteins. It is expressed on both axons and dendrites of neurons, and likely serves the critical function of directing the movement of low MW contactin, AMPA receptors, and Na+ plus K+ channels to appropriate sites on the cell membrane. This indicates participation in key processes such as myelination and excitatory neurotransmission. Mature human CASRP1 is a 1365 amino acid (aa) type I transmembrane protein. It contains a 1264 aa extracellular region (aa 20-1283) plus an 80 aa cytoplasmic domain. The extracellular region is highly modular, possessing one discoidin (carbohydrate-binding) domain (aa 24-158), four laminin G-like domains (aa 203-513, 813-956 and 1088-1250), two EGF-like domains (aa 540-577 and 957-996) and one fibrinogen C-terminal globular regions (aa 576-795). There is one potential alternative start site at Met507. Over aa 20-1280, human CASPR1 shares 94% aa sequence identity with mouse CASPR1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IHC.

Showing Publication 1 - 1 of 1.

Publication using AF7548	Applications	Species
Sosunov A, Wu X, Tsankova N, Guilfoyle E, McKhann G, Goldman J Phenotypic heterogeneity and plasticity of isocortical and hippocampal astrocytes in the human brain. J Neurosci, 2014-02-05;34(6):2285-98. 2014-02-05 [PMID: 24501367] (IHC, Human)	IHC	Human

Array AF7548

• Caspr1 Antibodies
• Caspr1 ELISA Kit
• Caspr1 Lysate
• Caspr1 Protein
• Caspr1 Proteins and Enzyme