CaM Kinase II alpha Antibody (6G9)

CaMKII is an important member of calcium/calmodulinactivated protein kinase family, functioning in neural synaptic stimulation and T-cell receptor signaling (1, 2). CaMKII is expressed in many different tissues but is specifically found in the neurons of the forebrain and its mRNA is found within the dendrites and the soma of the neuron. The CaMKII that is found in the neurons consist of two subunits of 52 (termed alpha genes) and 60 kDa (beta genes). CaMKII has catalytic and regulatory domains, as well as an ATP-binding domain, and a consensus phosphorylation site (3-7). The binding of Ca2+/calmodulin to its regulatory domain releases its auto inhibitory effect and activates the kinase (8). This kinase activation results in autophosphorylation at threonine 286 (8). The threonine phosphorylation state of CaMKII can be regulated through PP1/PKA. Whereas PP1 (protein phosphatase 1) dephosphorylates phospho-CaMKII at Thr286, PKA (protein kinase A) prevents this dephosphorylation (9). Autophosphorylation also enables CaMKII to attain an enhanced affinity for NMDA receptors in postsynaptic densities (10-12).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Mouse, Rat, Xenopus.

We have publications tested in 5 applications: Block/Neutralize, ICC/IF, IF/IHC, IP, WB.

Showing Publications 1 - 10 of 14. Show All 14 Publications. Collapse Publications.

Publications using NB100-1983	Applications	Species
Ameen SS, Griem-Krey N, Dufour A et al. N-Terminomic Changes of Neurons During Excitotoxicity Reveal Proteolytic Events Associated with Synaptic Dysfunctions and Potential Targets for Neuroprotection Molecular & cellular proteomics : MCP 2023-04-06 [PMID: 37030595] (WB, Mouse)	WB	Mouse
Rigter PMF, de Konink C, van Woerden GM. Loss of CAMK2G affects intrinsic and motor behavior but has minimal impact on cognitive behavior Frontiers in Neuroscience 2023-01-06 [PMID: 36685241] (Block/Neutralize)	Block/Neutralize
Rigter PMF, Wallaard I, Aghadavoud Jolfaei M et al. Adult Camk2a gene reinstatement restores the learning and plasticity deficits of Camk2a knockout mice iScience 2022-11-18 [PMID: 36304100] (IP, IF/IHC, WB, Mouse)	IP, IF/IHC, WB	Mouse
Griem-Krey N, Gauger SJ, Gowing EK et al. The CaMKIIa hub ligand Ph-HTBA promotes neuroprotection after focal ischemic stroke by a distinct molecular interaction Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022-10-20 [PMID: 36274464] (WB, Mouse)	WB	Mouse
Schiapparelli LM, Sharma P, He HY et al. Proteomic screen reveals diverse protein transport between connected neurons in the visual system Cell reports 2022-01-25 [PMID: 35081342] (WB, Rat)	WB	Rat
Schiapparelli LM, Shah SH, Ma Y et al. The Retinal Ganglion Cell Transportome Identifies Proteins Transported to Axons and Presynaptic Compartments in the Visual System In Vivo Cell Rep 2019-08-13 [PMID: 31412257] (WB, Rat)	WB	Rat
Koene LMC, van Grondelle SE, Proietti Onori M et al. Effects of antiepileptic drugs in a new TSC/mTOR-dependent epilepsy mouse model Ann Clin Transl Neurol 2019-07-01 [PMID: 31353861] (IF/IHC, Mouse)	IF/IHC	Mouse
Fang Q, Li Z, Huang GD et al. Traumatic Stress Produces Distinct Activations of GABAergic and Glutamatergic Neurons in Amygdala. Front Neurosci 2018-08-21 [PMID: 30186100] (ICC/IF, Rat)	ICC/IF	Rat
Liu H. H, McClatchy D. B, et al. Role of the visual experience-dependent nascent proteome in neuronal plasticity. Elife 2018-02-07 [PMID: 29412139] (WB, Xenopus)	WB	Xenopus
Li Y, You QL, Zhang SR et al. Satb2 Ablation Impairs Hippocampus-Based Long-Term Spatial Memory and Short-Term Working Memory and Immediate Early Genes (IEGs)-Mediated Hippocampal Synaptic Plasticity. Mol. Neurobiol. 2017-04-18 [PMID: 28421537] (WB, ICC/IF, Mouse)	WB, ICC/IF	Mouse
Hamada S, Ogawa I, Yamasaki M et al. The glutamate receptor GluN2 subunit regulates synaptic trafficking of AMPA receptors in the neonatal mouse brain Eur. J. Neurosci. 2014-08-08 [PMID: 25131300]
Balu Darrick T, Takagi Shunsuke, Puhl Matthew D et al. D-serine and serine racemase are localized to neurons in the adult mouse and human forebrain. Cell Mol Neurobiol. 2014-01-17 [PMID: 24436034]
George J, Baden DG, Gerwick WH, Murray TF. Bidirectional influence of sodium channel activation on NMDA receptor-dependent cerebrocortical neuron structural plasticity Proc Natl Acad Sci U S A 2012-11-27 [PMID: 23150561] (WB, Mouse)	WB	Mouse
Tianshu Feng, Eva Szabo, Ewa Dziak Michal Opas. Cytoskeletal Disassembly and Cell Rounding Promotes Adipogenesis from ES Cells. Stem Cell Reviews and Reports Volume 6, Number 1, 74-86. [PMID: 20148318]
Show All 14 Publications. Collapse Publications.

Array NB100-1983

• CaM Kinase II alpha Antibodies
• CaM Kinase II alpha ELISA Kits
• CaM Kinase II alpha Lysate
• CaM Kinase II alpha Proteins